Browning 촉진에 관여하는 최근 천연물의 동향

국문 초록 (Abstract)

전세계적으로 비만의 유병률은 증가하고 있으며 비만 유행은 식이요인과 좌식 생활 방식과 관련이 있기 때문에 현대인에게 발병하기 쉬운 질병이다. 또한 비만은 당뇨병, 심혈관계 질환과 같이 심각한 합병증을 동반하기 때문에 비만을 예방하고 치료하는 것이 중요해지고 있다. 현재 Liraglutide와 phentermine과 같은 의약품이 식욕억제 및 위장관 운동 지연을 유도해 비만 치료를 하고자 사용되고 있지만 갑상선암, 심혈관계 부작용, 중추 신경계 부작용 등 다양한 부작용이 발생하는 것으로 알려져있다. 따라서 상대적으로 부작용이 적은 비만 치료 방법을 탐색하기 위해 백색 지방조직을 갈색조직지방으로 바꾸어 에너지 소비를 증가시켜 비만을 치료하는 “Fat browning”이라는 방법이 도입되었다. 임상적으로 안전하게 “browning”을 유도하기 위해 효과 있는 천연 물질을 탐색하기 위한 연구가 진행중이며 현재 많은 천연물 소재가 연구되었다. 천연 물질 치료를 통한 “Browning” 유도는 일반적으로 “Browning” 유도 인자의 긍정적인 제어, 백색지방조직으로의 분화 억제, “Browning“과 관련된 메커니즘의 활성화의 세 가지를 포함한다. 따라서 Strawberry, Black raspberry, Cinnamomum cassia, Ecklonia stolonifera와 같은 “Browning” 유도 효과가 알려진 식물 추출물에 대한 연구를 설명한다. 우리는 또한 이러한 추출물이 “Browning”을 유도하고 그들이 매개하는 신호 경로를 통해 지금까지 확인된 메커니즘을 요약한다. 나아가 Browning을 통해 생성된 갈색지방조직이 내분비 기관으로써 심장 질환에 미치는 영향까지 확인해본 후 정리했다.

다국어 초록 (Multilingual Abstract)

The prevalence of obesity is increasing worldwide, and since obesity is associated with dietary factors and sedentary lifestyles, it is a disease that is readily developing in the modern population. Because obesity is accompanied by serious complications such as diabetes and cardiovascular disease, prevention and treatment are important. Currently, drugs such as liraglutide and phentermine are used to treat obesity by suppressing appetite and inducing gastrointestinal motility delay. However, various side effects may occur, including thyroid cancer, cardiovascular problems, and central nervous system disorders. Therefore, to explore an obesity treatment method with relatively few side effects, a method known as “fat browning” was introduced to change white adipose tissue into brown adipose tissue to increase energy consumption. Ongoing studies are attempting to find effective natural substances to safely induce browning. Many natural substances have been identified. The induction of browning by treatment with natural substances generally involves three mechanisms: positive control of browning-inducing factors, inhibition of differentiation into white adipose tissue, and the activation of mechanisms related to browning. In this study, we describe plant extracts with known browning-inducing effects, such as strawberry, black raspberry, cinnamomum cassia, and Ecklonia stolonifera extracts. We also summarize the underlying mechanisms of action identified thus far, including the signaling pathway mediated by these extracts to induce browning. Furthermore, the effects of brown adipose tissue generated through browning on heart disease as an endocrine organ disruptor are discussed.

목차 (Table of Contents)

• 서론
• 본론
• 결론
• References
• 초록

참고문헌 (Reference)

1 박경수, "혈중 아디포카인 농도와 대사지표와의 상관관계" 대한내분비학회 20 (20): 441-443, 2005

2 김재범, "지방세포 분화와 지방세포 분비물질들의 기능" 대한내분비학회 17 (17): 1-9, 2002

3 Haslam, D., "Weight management in obesity–past and present" 70 : 206-217, 2016

4 Connolly, H. M., "Valvular heart disease associated with fenfluramine–phentermine" 337 : 581-588, 1997

5 Vargas Castillo, A., "Understanding the biology of thermogenic fat : is browning a new approach to the treatment of obesity?" 48 : 401-413, 2017

6 Gallo, M., "Thyroid safety in patients treated with liraglutide" 36 : 140-145, 2013

7 Goldgof, M., "The chemical uncoupler 2, 4-dinitrophenol(DNP)protects against diet-induced obesity and improves energy homeostasis in mice at thermoneutrality" 289 : 19341-19350, 2014

8 Joshi, T., "Targeting AMPK signaling pathway by natural products for treatment of diabetes mellitus and its complications" 234 : 17212-17231, 2019

9 Forbes Hernández, T. Y., "Strawberry (Fragaria×ananassa cv. Romina) methanolic extract promotes browning in 3T3-L1 cells" 11 : 297-304, 2020

10 Seo, Y. J., "Spirulina maxima extract reduces obesity through suppression of adipogenesis and activation of browning in 3T3-L1 cells and high-fat diet-induced obese mice" 10 : 712-, 2018

11 Picard, F., "Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-γ" 429 : 771-776, 2004

12 Nemoto, S., "SIRT1functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1α" 280 : 16456-16460, 2005

13 전상민, "Regulation and function of AMPK in physiology and diseases" 생화학분자생물학회 48 : 1-13, 2016

14 Peng, Ma., "Recent developments in natural products for white adipose tissue browning" 18 : 803-817, 2020

15 Tseng, H. H., "Proteomic profiling of Ganoderma tsugae ethanol extract-induced adipogenesis displaying browning features" 592 : 1643-1666, 2018

16 Douglas, A., "Plasma phentermine levels, weight loss and side-effects" 7 : 591-595, 1983

17 Cheng, P., "Physiological and pharmacological roles of FGF21 in cardiovascular diseases" 2016 : 1540267-, 2016

18 Ahmadian, M., "PPARγ signaling and metabolism : the good, the bad and the future" 19 : 557-566, 2013

19 Kopelman, P. G., "Obesity as a medical problem" 404 : 635-643, 2000

20 Villarroya, J., "New insights into the secretory functions of brown adipose tissue" 243 : R19-R27, 2019

21 Govoni, S., "NGF and heart : Is there a role in heart disease?" 63 : 266-277, 2011

22 Whitten, J. S., "Liraglutide(Saxenda)for weight loss" 94 : 161-166, 2015

23 Villarroya, F., "Irisin, turning up the heat" 15 : 277-278, 2012

24 Kuryłowicz, A., "Induction of adipose tissue browning as a strategy to combat obesity" 21 : 6241-, 2020

25 Chou, Y. C., "Immature Citrus reticulata extract promotes browning of beige adipocytes in high-fat diet-induced C57BL/6 mice" 66 : 9697-9703, 2018

26 Chen, L. H., "Green tea extract induces genes related to browning of white adipose tissue and limits weight-gain in high energy diet-fed rat" 61 : 1347480-, 2017

27 Lanzi, C. R., "Grape pomace extract supplementation activates FNDC5/irisin in muscle and promotes white adipose browning in rats fed a high-fat diet" 11 : 1537-1546, 2020

28 Watanabe, M., "GABA and GABA receptors in the central nervous system and other organs" 213 : 1-47, 2002

29 Choi, E. W., "Fas mutation reduces obesity by increasing IL-4 and IL-10 expression and promoting white adipose tissue browning" 10 : 1-14, 2020

30 Nagase, I., "Expression of uncoupling protein in skeletal muscle and white fat of obese mice treated with thermogenic beta 3-adrenergic agonist" 97 : 2898-2904, 1996

31 Lee, S. G., "Enhancement of the Antiobesity and antioxidant effect of purple sweet potato extracts and enhancement of the effects by fermentation" 10 : 888-, 2021

32 Jin, H., "Ecklonia stolonifera extract suppresses lipid accumulation by promoting lipolysis and adipose browning in high-fat diet-induced obese male mice" 9 : 871-, 2020

33 Sun, Y. S., "Dietary Apigenin promotes lipid catabolism, thermogenesis, and browning in adipose tissues of HFD-Fed mice" 133 : 110780-, 2019

34 Ferrer Lorente, R., "Combined effects of oleoyl-estrone and a β3-adrenergic agonist(CL316, 243)on lipid stores of diet-induced overweight male Wistar rats" 77 : 2051-2058, 2005

35 Li, X., "Cinnamomum cassia extract promotes thermogenesis during exposure to cold via activation of brown adipose tissue" 266 : 113413-, 2021

36 Jeremic, N., "Browning of white fat : novel insight into factors, mechanisms, and therapeutics" 232 : 61-68, 2017

37 Ahmad, B., "Brown/beige adipocytes originate from distinct precursor cells and secrete various factors known as batokines. The batokines then target distant organs and tissues and perform various functions in an autocrine, paracrine, and endocrine manner Brown/Beige adipose tissues and the emerging role of their secretory factors in improving metabolic health: The batokines" 184 : 26-39, 2021

38 Park, W. Y., "Black Raspberry (Rubus coreanus miquel) Promotes browning of preadipocytes and inguinal white adipose tissue in cold-induced mice" 11 : 2164-, 2019

39 Rothman, R. B., "Amphetamine-type central nervous system stimulants release norepinephrine more potently than they release dopamine and serotonin" 39 : 32-41, 2001

40 Funch, D., "A prospective, claims-based assessment of the risk of pancreatitis and pancreatic cancer with liraglutide compared to other antidiabetic drugs" 16 : 273-275, 2014