Front Cover: Quantity determination analysis of etodolac and thiocolchicoside combination with inverse phase‐liquid chromatography method in human plasma

다국어 초록 (Multilingual Abstract)

DOI: 10.1002/sscp.201900036
The cover picture shows an easy, fast, economical, repeatable, sensitive and new Reverse Phase‐High Performance Liquid Chromatography method been developed for the simultaneous quantitative estimation of Etodolac and Thiocolchicoside combination in human plasma (in‐vitro). Three‐dimensional spectrum of Thiocolchicoside and Etodolac in plasma. Determination of Etodolac and Thiocolchicoside without any need for extraction process in human plasma was carried out at 259 nm by using Photo Diode Array Detector as seen from the three‐dimensional spectrum of Thiocolchicoside and Etodolac in plasma. Very high recovery values as 97.50–100.24% for Etodolac and 97.21–100.68% for Thiocolchicoside were obtained. Furthermore, an environmental friendly and more economical method was developed by decreasing the methanol rate within the mobile phase mixture. This method was also applied in human plasma media and it was seen that it can be easily and successfully applied in routine quantity analysis processes.