트레드밀운동이 Streptozotocin 유도 당뇨쥐의 심근 세포기질 LDH 동위효소 발현에 미치는 영향 = The Effects of Treadmill Exercise on Cytosolic LDH Isozymes Expression of Cardiac Muscle in the Streptozotocin-induced Diabetic Rats

다국어 초록 (Multilingual Abstract)

The purpose of this study was to investigate the expression of treadmill exercise on lactate dehydrogenase (LDH) isozymes in the diabetic rats heart. For this study, twenty male F344 rats were assigned to control group (n = 10), control exercise group (n = 10), diabetes group (n = 10) and diabetic exercise group (n = 10). 10 rats were trained according to exercise program for 6 weeks and 10 rats were untrained for control group. The change of cytosolic LDH isozymes activity of cardiac tissue were measured after 6 weeks training in rats. Polyacrylamide gel electrophoresis was performed after exercise training. Relative activity (%) of cardiac cytosolic LDH isozymes for control and exercise group on the gel electrophoresis showed the following order of prevalence : AB₃＞A₂B₂＞B₄＞A₃B＞A₄, for diabetic group and diabetic exercise group : AB₃＞B₄＞A₂B₂＞A₃B＞A₄. These results suggest that exercise training effect on not only normal cardiac tissue cytosolic LDH isozymes activity but also diabetic cardiac tissue LDH isozymes activity and LDH A₄, A₃B₂, A₂B₂, AB₃ and B₄ isozymes were found entirely in cytosol, but there was no LDH A₄ isozyme in the diabetes rats.

목차 (Table of Contents)

• Abstract
• 1. 서론
• 2. 연구 방법
• 3. 결과
• 4. 고찰
• 5. 결론
• 인용문헌

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