慢性活動性肝炎에 있어서 Leukocyte Adherence Inhibition(LAI)에 關한 硏究 = Leukocyte Adhesion Inhibition( LAI ) in Patients with Chronic Active Hepatitis

다국어 초록 (Multilingual Abstract)

Leukocyte adgerence inhibition(LAI) assay of the peripheral blood mononuclear cells, which can determine cell mediated immunity(CMI), was performed by tubs method to evaluate the pathogenesis of chronic active hepatitis arised from host immune dysfunction. In group of normal healed persons(group Ⅰ) NAI was 47.6±8.7(mean±SD)%. In group of patients with chronic active hepatitis(group Ⅲ) NAI was 17.8±6.8%, which was lesser than half level of that in group Ⅰ, therefore significant impairement of CMI was suggested. In group of chronic carriers(group Ⅱ) NAI was 8.2±4.0%, as low as normal control group, in which NAI level was 8.2±4.0%, as a result it was predicted that immune tolernane was exerted on chronic carrier state.
To determine indicator cells of LAI reaction, the LAI assay was investigated with mononuclear cell subpopulations defined by monoclononal antibodies. The Anti-Leu-2a(CD3) positive cells only have significant reactivity, so it suggested that such cells are major involved cells in CMI against hepatitis B viral infection.