알코올에 의한 α-Tocopherol이 혈액성분 및 간조직에 미치는 영향에 관한 연구 = Studies on the Effects of Blood Components and Hepatic Tissue of α-Tocopherol in the Ethanol Administered Rat

다국어 초록 (Multilingual Abstract)

This study was done in order to observe the effects of ethanol and a-tocopherol on the HDL-chelesterol, r-GTP, CPK, aminotransferase(AST-ACT) and histopathologic findings.
The white Sprague Dawley rat were Classified into 4 groups:0.9% NaCl ad-ministration was group A 25% ethanol administration for the each 5,10 and 15 days was ethanol group B(BI, B2 and B3), 25% ethanol administration for th each 5 and 10 days, and 50% a-tocopherol for the 2 and 7 days administration was group C(CI and C2), 50% a-tocopherol pretreated for the each 5, 10 and 16 days and 25% ethanol for the 2,7 and 10 days administration was group D(D1, D2 and D3).
The following results were obtained
1. The Biochemical changes of serum HDL-cholesterol, r-GTP, CPK, GOT and GPT activities was significantly increased in ethanol treated group than group D.(D1, D2 and D3).
2. The Biochemical changes of each subgroup in ethanol treated group HDL-cholesterol was most highly increased. The group C1 and DI was near normal.
3. The change of r-GTP activity of each subgroup in ethanol treated group was highly increased than the group B1, The Cl and Dl groups was near normal.
4. The change of CPK activity of each subgroup in ethanol treated group was most highly in creased than the B3 group. the group Cl and Dl groups was near normal.
5. The change of GOT and GPT activities of each subgroups in B3 and D3 was most highly increased but the C2 and D2 was not significant.
6. The histopathological changes of ethanol treated group(B2, and B3) found the lipid droplet and infiltration of inflammatory cells, and mild ballooning degeneration. The group C3 and D3 found the mild infiltration and lipid droplet.