제왕절개술을 위한 척추마취에서 Bupivacaine-Fentanyl과 Bupivacaine-Alfentanil의 효과 및 부작용 비교 = Comparison of Intrathecal Bupivacaine-Alfentanil and Bupivacaine-Fentanyl in Spinal Anesthesia for Cesarean Section

다국어 초록 (Multilingual Abstract)

Background: Additive opioids in spinal anesthesia of cesarean
section decrease the dose of local anesthetics and increase the
quality of anesthesia. There were comparative studies about
morphine, fentanyl, and sufentanil as an additive opioid in spinal
anesthesia of cesarean section, but few studies about alfentanil.
In this study we compared the effect of alfentanil with fentanyl as
an additive opioid in spinal anesthesia for cesarean section.
Methods: Sixty nine pregnant women, American Society of
Anesthesiologist (ASA) I-II, who were scheduled for elective
cesarean section under spinal anesthesia, were randomly allocated
into two groups: group F received 8 mg (1.6 ml) of bupivacaine
and 15μg of fentanyl (0.3 ml) intrathecally, and group A received
8 mg of bupivacaine and 150μg of alfentanil (0.3 ml). Sensory
block defined by pin-prick, intraoperative patient satisfaction for
analgesia by visual analogue scale (VAS), blood pressure, and side
effects were assessed. Apgar score and umbilical arterial blood
gas analysis were also assessed.
Results: The analgesic effect of alfentanil was as good as fentanyl
and VAS for satisfaction was 97.1 ± 7.6 and 96.5 ± 8.0 each. Time
to achieve anesthetic level of T6 (6.2 vs 6.7 min), maximal block
level (T3.7 vs T3.8), lowest blood pressure during the operation
(60.0 vs 61.0 mmHg), duration of analgesia (77.2 vs 70.0 min), and
fetal assessment were not different from those of group F, either.
The incidence of nausea during operation was 48.6% in group F
and 26.4% in group A (P = 0.14),
Conclusions: The addition of alfentanil is comparable to fentanyl
in analgesia, maternal and fetal effects in spinal anesthesia for
cesarean section.

참고문헌 (Reference)

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