아랫입술에 발생한 육종성 편평세포암 = Sarcomatoid Squamous Cell Carcinoma of the Lower Lip: A Case Report

다국어 초록 (Multilingual Abstract)

Sarcomatoid squamous cell carcinoma (SSCC) is a rare malignancy with distinct carcinomatous and sarcomatous features. SSCCs involving the lung, esophagus bladder, and skin have been reported as rare case reports. It may also occur infrequently in the oral region. Moreover, the lower lip is still one of the rare sites, and such a case has not been reported in Korean literature. An 82-year-old man presented an exophytic protruding, huge, warty crusted lesion on the entire lower lip. The lesion started as a small, tender, erosive papule and suddenly enlarged in recent months. His medical history was unremarkable. A biopsy revealed atypical squamous and sarcomatous components with transition zones between the two cell types. These two cell types also showed characteristic immunohistochemical features. Based on these findings, the lesion was diagnosed as SSCC. The study, including positron emission tomography-computed tomography, showed no metastasis. We recommended surgical excision, but the patient refused therapy. (Korean J Dermatol 2021;59(8):640∼643)

참고문헌 (Reference)

1 김민수, "하지에 발생한 방추상 세포 편평세포암 1예" 대한피부과학회 51 (51): 623-626, 2013

2 김찬우, "피부의 방추상 세포 편평세포암 1예" 대한피부과학회 45 (45): 283-286, 2007

3 송기훈, "두피에 발생한 원발성 암육종" 대한피부과학회 51 (51): 928-930, 2013

4 George W. Greene, "Spindle-cell squamous carcinoma of the lip" Elsevier BV 12 (12): 1008-1016, 1959

5 Gary L. Ellis, "Spindle cell carcinoma of the oral cavity" Elsevier BV 50 (50): 523-534, 1980

6 K OLSEN, "Spindle cell carcinoma of the larynx and hypopharynx☆☆☆" SAGE Publications 116 (116): 47-52, 1997

7 George S. Leventon, "Sarcomatoid squamous cell carcinoma of the mucous membranes of the head and neck: A clinicopathologic study of 20 cases" Wiley 48 (48): 994-1003, 1981

8 Bo Young Kim, "Sarcomatoid carcinoma after radiotherapy for early-stage oral squamous cell carcinoma" Ovid Technologies (Wolters Kluwer Health) 98 (98): e16003-, 2019

9 Nai-Jen Chang, "Sarcomatoid Carcinoma in Head and Neck" Ovid Technologies (Wolters Kluwer Health) 71 (71): S1-S7, 2013

10 Liu J, "Oral sarcomatoid squamous cell carcinoma : a retrospective study based on 14 cases" 35 : 385-394, 2020

11 Dulce M. Barrios, "Immune checkpoint inhibitors to treat cutaneous malignancies" Elsevier BV 83 (83): 1239-1253, 2020

12 Virchow R, "Die krankhaften Geschwülste: dreissig Vorlesungen, gehalten während des Wintersemesters 1862-1863an der Universität zu Berlin" Hirschwald 1865

13 Tien Anh Tran, "Cutaneous carcinosarcoma: adnexal vs. epidermal types define high- and low-risk tumors. Results of a meta-analysis" Wiley 32 (32): 2-11, 2005

14 Tze Ling Loh, "Cutaneous Carcinosarcoma with Metastasis to the Parotid Gland" Hindawi Limited 2014 : 1-4, 2014

15 Michael R Migden, "Cemiplimab in locally advanced cutaneous squamous cell carcinoma: results from an open-label, phase 2, single-arm trial" Elsevier BV 21 (21): 294-305, 2020

16 Wojciech Biernat, "Carcinosarcoma of the Skin" Ovid Technologies (Wolters Kluwer Health) 18 (18): 614-619, 1996

17 Rebecca F. Rose, "Basal cell carcinoma with a sarcomatous component (carcinosarcoma): A series of 5 cases and a review of the literature" Elsevier BV 59 (59): 627-632, 2008