Slide Session : OS-NEP-03 ; Nephrology : Serum Phosphorus Level and Coronary Artery Calcifi cation in Subjects without Renal Dysfunction = Slide Session : OS-NEP-03 ; Nephrology : Serum Phosphorus Level and Coronary Artery Calcifi cation in Subjects without Renal Dysfunction

다국어 초록 (Multilingual Abstract)

Background: Serum phosphorus (P) level is associated with coronary artery calcifi cation as well as cardiovascular events in patients with chronic kidney disease. However, this relationship has been debated in normal subjects without renal dysfunction. Methods: A cross-sectional study was undertaken in 2,503 Korean subjects who underwent coronary multi-detector computerized tomography for screening and had estimated glomerular fi ltration rate >60 ml/min/1.73m². The study subjects were divided into 3 groups according to Agatston score: 0 (n=1582), >0 to 100 (n=613), and >100 (n=308). Serum P concentration was divided to 4 categories: =3.2, >3.2 to 3.6, >3.6 to 4.0 and >4.0 mg/dL. A baseline-category (Agatston score=0) logit model was applied to estimate relative risk ratio (RRR) for each serum P category (reference: =3.2 mg/ dL) with adjustment for age, sex, body mass index, corrected serum calcium, albumin, non-high density lipoprotein (HDL) and HDL cholesterol concentration. Results: Mean (±SD) age of subjects was 53.5±9.1 years and 36.9% were females. Increase in serum P level was not associated with the risk of Agatston scores of >0 to 100. When subjects with Agatston score =0 or >100 were analyzed, higher serum P levels were associated with higher risk of having Agatston scores of >100 (Figure). Serum P level of >4.0 mg/dL was a signifi cant and independent risk factor for Agatston scores of >100 (RRR 1.78, 95% confi dence interval 1.14-2.78). Conclusions: Higher serum P level may be associated with higher coronary artery calcifi cation even in healthy subjects with normal renal function. This fi nding needs to be validated in diverse populations.