The relationship between ovarian volume and related clinical-hormonal parameters in Korean women with polycystic ovary syndrome = The relationship between ovarian volume and related clinical-hormonal parameters in Korean women with polycystic ovary syndrome

다국어 초록 (Multilingual Abstract)

Objective: The aim of this study was to evaluate the relationship between ovarian volume and clinical-hormonal parameters including anti-Mullerian hormone (AMH) in Korean women with polycystic ovary syndrome (PCOS).
Methods: A total of 94 Korean women aged 20 to 40 years were included in this study and they were newly diagnosed with PCOS using 2003 revised Rotterdam criteria at Pusan national university hospital. The volumes of each ovary were measured using ultrasonography at the time of diagnosis. The clinical parameters, such as hirsutism, acne, alopecia and oligo-anovulation were investigated. The hormonal parameters including serum follicle-stimulating hormone (FSH), luteinizing hormone (LH), total testosterone, free testosterone, dehydroepiandrosterone sulfate (DHEA-S) and AMH levels were measured in the early follicular phase. The correlation between ovarian volume and clinical-hormonal parameters was investigated using Pearsons correlation coefficients and linear regression analysis.
Results: Mean ovarian volume had positive correlation with only serum total testosterone (r = 0.244, p = 0.046), but had no correlation with serum AMH (r = 0.128, p = 0.244), free testosterone (r = 0.098, p = 0.429), hirsutism (r = -0.064, p = 0.542), acne (r = -0.028, p = 0.787), alopecia (r = 0.045, p = 0.665) or irregular menstruation (r = 0.132, p = 0.203). Serum AMH levels had negative correlation with body mass index (r = -0.266, p = 0.014).
Conclusion: Mean ovarian volume had weakly positive correlation with serum AMH levels, but it showed no statistical significance. Therefore, we should be more cautious when using AMH levels as surrogate for ultrasonographic appearance in PCOS patients.