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The aim of this study was to determine whether tumor‐associated immune cells may predict response to therapy and disease outcome in head and neck squamous cell carcinoma (HNSCC) patients receiving induction chemotherapy and cetuximab. Paraffin‐emb...
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RISS 인기검색어
Local immune parameters as potential predictive markers in head and neck squamous cell carcinoma patients receiving induction chemotherapy and cetuximab
한글로보기https://www.riss.kr/link?id=O119276423
- 저자
- 발행기관
- 학술지명
- 권호사항
-
발행연도
2019년
-
작성언어
-
-
Print ISSN
1043-3074
-
Online ISSN
1097-0347
-
등재정보
SCI;SCIE;SCOPUS
-
자료형태
학술저널
-
수록면
1237-1245 [※수록면이 p5 이하이면, Review, Columns, Editor's Note, Abstract 등일 경우가 있습니다.]
-
구독기관
- 전북대학교 중앙도서관
- 성균관대학교 중앙학술정보관
- 부산대학교 중앙도서관
- 전남대학교 중앙도서관
- 제주대학교 중앙도서관
- 중앙대학교 서울캠퍼스 중앙도서관
- 인천대학교 학산도서관
- 숙명여자대학교 중앙도서관
- 서강대학교 로욜라중앙도서관
- 계명대학교 동산도서관
- 충남대학교 중앙도서관
- 한양대학교 백남학술정보관
- 이화여자대학교 중앙도서관
- 고려대학교 도서관
-
0
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부가정보
다국어 초록 (Multilingual Abstract)
The aim of this study was to determine whether tumor‐associated immune cells may predict response to therapy and disease outcome in head and neck squamous cell carcinoma (HNSCC) patients receiving induction chemotherapy and cetuximab.
Paraffin‐embedded pretreatment biopsy samples from 45 patients with stage III‐IV resectable HNSCC were investigated retrospectively by immunohistochemistry for density of different immune cell types based on expression of CD8, FOXP3, CD134, CD137, PD‐1, CD20, NKp46, dendritic cell lysosomal‐associated membrane protein (DC‐LAMP), CD16, CD68, and myeloperoxidase. Results were analyzed for possible correlations with clinicopathologic parameters, response to therapy, and survival.
Of the immune cell types studied, we found significant association with response to induction chemotherapy only in the case of DC‐LAMP+ mature dendritic cells and PD‐1+ lymphocytes; density of DC‐LAMP+ cells also correlated with progression‐free survival.
DC‐LAMP+ mature dendritic cells and PD‐1+ cells may be implicated in response to induction chemotherapy and cetuximab in HNSCC patients.
Paraffin‐embedded pretreatment biopsy samples from 45 patients with stage III‐IV resectable HNSCC were investigated retrospectively by immunohistochemistry for density of different immune cell types based on expression of CD8, FOXP3, CD134, CD137, PD‐1, CD20, NKp46, dendritic cell lysosomal‐associated membrane protein (DC‐LAMP), CD16, CD68, and myeloperoxidase. Results were analyzed for possible correlations with clinicopathologic parameters, response to therapy, and survival.
Of the immune cell types studied, we found significant association with response to induction chemotherapy only in the case of DC‐LAMP+ mature dendritic cells and PD‐1+ lymphocytes; density of DC‐LAMP+ cells also correlated with progression‐free survival.
DC‐LAMP+ mature dendritic cells and PD‐1+ cells may be implicated in response to induction chemotherapy and cetuximab in HNSCC patients.
The aim of this study was to determine whether tumor‐associated immune cells may predict response to therapy and disease outcome in head and neck squamous cell carcinoma (HNSCC) patients receiving induction chemotherapy and cetuximab.
Paraffin‐embedded pretreatment biopsy samples from 45 patients with stage III‐IV resectable HNSCC were investigated retrospectively by immunohistochemistry for density of different immune cell types based on expression of CD8, FOXP3, CD134, CD137, PD‐1, CD20, NKp46, dendritic cell lysosomal‐associated membrane protein (DC‐LAMP), CD16, CD68, and myeloperoxidase. Results were analyzed for possible correlations with clinicopathologic parameters, response to therapy, and survival.
Of the immune cell types studied, we found significant association with response to induction chemotherapy only in the case of DC‐LAMP+ mature dendritic cells and PD‐1+ lymphocytes; density of DC‐LAMP+ cells also correlated with progression‐free survival.
DC‐LAMP+ mature dendritic cells and PD‐1+ cells may be implicated in response to induction chemotherapy and cetuximab in HNSCC patients.
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