Preparation of blue-color-emitting graphene quantum dots and their in vitro and in vivo toxicity evaluation

다국어 초록 (Multilingual Abstract)

We synthesized and characterized blue-color-emitting graphene quantum dots (BGQDs) which is betterthan that of other GQDs synthesized from organic molecules. We investigated the biocompatibility ofBGQDs with cells and erythrocytes. Evaluation of epithelial carcinoma cancer cells indicated that mostcells successfully took up BGQDs and toxicity testing showed no effect on cell viability. We also examinedalterations in deformability and aggregation of human erythrocytes exposed to BGQDs at differentconcentrations and incubation times. These results suggest that BGQDs are biocompatible and do notcause cell membrane damage, and thus, are promising nanomaterials for various medical diagnoses andtreatments.

참고문헌 (Reference)

1 S. Gurunathan, 11 : 1927-, 2016

2 S. Wang, 6 : 89867-, 2016

3 K.L. Schroeder, 33 : 2337-, 2016

4 M. Bacon, 31 : 415-, 2014

5 S. Zhuo, 6 : 1059-, 2012

6 M. Nurunnabi, 49 : 5079-, 2013

7 R. Liu, 133 : 15221-, 2011

8 Y. Dong, 50 : 4738-, 2012

9 Q. Liu, 13 : 2436-, 2013

10 X. Yuan, 9 : 1-, 2014

11 M. Nurunnabi, 7 : 6858-, 2013

12 D. Jiang, 10 : e0144906-, 2015

13 Y. Chong, 35 : 5041-, 2014

14 Y. Rodriguez-Yanez, 23 : 178-, 2013

15 M. Khan, 2 : 765-, 2015

16 J. Kim, 62 : 99-, 2016

17 M.J. Kim, 67 : 80-, 2014

18 K.H. Liao, 3 : 2607-, 2011

19 S.M. Chowdhury, 3 : 2584-, 2013

20 B. Cai, 356 : 844-, 2015

21 X. Wu, 1 : 4676-, 2013

22 S. Chandra, 1 : 2375-, 2013

23 M. Nafiujjaman, 3 : 5815-, 2015

24 M. Nafiujjaman, 51 : 5687-, 2015

25 J. Lin, 7 : 5320-, 2013

26 M. Nurunnabi, 5 : 8246-, 2013

27 O. Baskurt, 42 : 75-, 2009

28 S. Shin, 37 : 319-, 2007

29 S. Shin, 41 : 197-, 2009

30 J. Gu, 27 : 165704-, 2016

31 J. Gu, 4 : 50141-, 2014

32 C. Wang, 8 : 6621-, 2016

33 M. Schubert, 61 : 77-, 2005

34 Y. Liu, 51 : 4176-, 2015

35 M.A. Sk, 2 : 6954-, 2014

36 F. Pinaud, 27 : 1679-, 2006

37 H.S. Choi, 5 : 42-, 2010

38 H. Sun, 5 : 1174-, 2013