라세믹 드러그의 식별을 위한 Cellulose tris(3,5-dimethylphenylcarbamate)를 고정시킨 키랄 지르코니아 마이크로 자성구의 용이한 합성 : Facile Synthesis of Cellulose tris(3,5-dimethylphenylcarbamate) Immobilized Chiral Zirconia Magnetic Microspheres for the Discrimination of Racemic Drugs

다국어 초록 (Multilingual Abstract)

Separation of chiral compound is one of the most interesting and challenging tasks because of their identical physical and chemical properties and different behaviors in living system. The magnetic materials with chiral selector on their surface can provide not only magnetic property but also to selectivity for enantiomer. The Fe3O4@ZrO2 core-shell magnetic materials have not been reported previously for racemates separation. ZrO2 material as inorganic metal oxides has been shown to be most stable at oxide mechanical, thermal and chemical conditions, and shows better physical and chemical properties than other metal oxides. The present research shows core-shell microspheres composition of a Fe3O4 magnetic core and coated by a zirconia shell (Fe3O4@ZrO2) which provide site to graft with cellulose tris(3,5-dimethylphenylcarbamate) to gain chiral zirconia magnetic microspheres (CZMMs). As-synthesized CZMMs have been used for the separation of racemic drugs and the results suggest that the CZMMs have ability for enantioseparations. Additionally, the most important thing is that the synthesized CZMMs have shown an excellent recyclability and can be applied for more chiral separations of different kinds of racemates.
Keywords: Magnetic materials, Fe3O4@ZrO2 core-shell magnetic microspheres, CDMPC as chiral selector, Separation of racemic drugs.

목차 (Table of Contents)

• 1. INTRODUCTION 1
• 1.1. History of Chirality
• 1.2. Chiral Molecules
• 1.3. Importance of Chirality in the Biological
• 1.4. Racemic Drugs
• 1.4.1. Beta-Blockers (β-Blockers)
• 1.4.2. NonSteroidal Anti-Inflammatory Drugs (NSAIDs)
• 1.5. Polysaccharide as Chiral Selector
• 1.5.1. Historical Background
• 1.5.2. Phenylcarbamates of Cellulose as Polysaccharide Derivatives-
• based CSPs for Enantiomer Separation
• 1.6. Magnetic Nanoparticles (MNPs)
• 1.6.1. History
• 1.6.2. Properties
• 1.6.2.1. Finite-Size Effects
• 1.6.2.2. Surface Effect
• 1.7. Synthesis Methods of MNPs
• 1.7.1. Co-Precipitation
• 1.7.2. Thermal Decomposition
• 1.7.3. Microemulsion
• 1.7.4. Solvothermal
• 1.8. Why coated Zirconia (ZrO2) on MNPs?
• 1.9. Why used MNPs for Chiral Separation?
• 1.10. Summary and Outline
• 2. EXPERIMENT 28
• 2.1. Materials
• 2.2. Several type synthesis of Iron Oxide (Fe3O4)
• 2.2.1. First type synthesis of Iron Oxide (Fe3O4)
• 2.2.2. Second type synthesis of Iron Oxide (Fe3O4)
• 2.2.3. Third type synthesis of Iron Oxide (Fe3O4)
• 2.3. Preparation of Fe3O4@ZrO2 magnetic microspheres
• 2.3.1. Direct coated zirconia (ZrO2) on Iron Oxide (Fe3O4)
• 2.3.2. Two steps coated zirconia (ZrO2) on Iron Oxide (Fe3O4)
• 2.3.2.1. Step I: Synthesis of Fe3O4@C magnetic microspheres
• 2.3.2.2. Step II: Synthesis of Fe3O4@ZrO2 magnetic microspheres
• 2.4. Synthesis of CDMPC as Chiral Selector
• 2.5. Preparation of Chiral Zirconia Magnetic Microspheres (CZMMs)
• 2.6. Separation of Racemic Drugs by using CZMMs
• 2.7. Characterization Techniques
• 3. RESULT AND DISCUSSION 36
• 3.1. Transmission Electron Microscopy (TEM)
• 3.2. X-ray Diffraction (XRD)
• 3.3. Fourier Transform Infrared Spectroscopy (FT-IR)
• 3.4. Nuclear Magnetic Resonance (NMR)
• 3.5. X-ray Photoelectron Spectrometer (XPS)
• 3.6. Vibrating Sample Magnetometer (VSM)
• 3.7. Thermal Gravimetrical Analysis (TGA)
• 3.8. BET & Poresize Analysis
• 3.9. Analysis of Racemic Drugs by Polarimeter
• 4. CONCLUSION 62
• 5. LITERATURE CITED 63
• 6. ABSTRACT 70