Evaluation of Bone-union Efficiency of collagen coated Peek Using beagle dog

다국어 초록 (Multilingual Abstract)

Spinal fusion is a surgical procedure that reduce patient pain by relieving nerve compression due to disc degeneration. This procedure restores the disk height of the lowered intervertebral disc due to degeneration and fixes the movement of the vertebral segments in the lesion by inserting an implant in the spinal segment of the patient. However, there is a side effect that the patient’s postoperative recovery rate is slow and the movement of the lesion segment is not fixed effectively because of the delayed union between the inserted intervertebral body and the vertebra. In order to improve these problems, Jeil Medical Co, Ltd developed a product that coated the surface of PEEK with collagen and Osong Medical Innovation Foundation Laboratory Animal Center (KBIO-LAC) applied it to the tibia of beagle to evaluate its effectiveness. At 5 and 10 weeks after transplantation the tibia bone was removed and micro-CT and histology analysis were performed. Results of micro-CT analysis showed the BMD and bone volume of liquid collagen coated PEEK implants area were higher than those of other implants area at 5 and 10 weeks. Histological analysis of bone stained with Villanueva showed that the distribution of bone formation was greater in the periphery of the HA-blasting PEEK than in the periphery of the bare PEEK at 4 weeks of transplantation, and the density of the peripheral bone tissue of the HA-blasting PEEK at 8 weeks was higher than that of the bare PEEK. As a result, the effectiveness of HA blasting PEEK was confirmed, and it was found that the peripheral bone tissue was formed relatively better than bare PEEK.