Induction of Extracellular Matrix Synthesis in Normal Human Fibroblasts by Anthraquinone Isolated from Morinda citrifolia (Noni) Fruit

다국어 초록 (Multilingual Abstract)

In previous studies we found that Morinda citrifolia (Noni) fruit extract up-regulated biosynthesis of type Icollagen and glycosaminoglycans in primary cultures of normal human fibroblasts. The objective of this study was to iden-tify the active ingredients in Noni fruit extract. An active single compound having a type I collagen-stimulating effect wasisolated and identified as 1,4-dihydroxy-2-methoxy-7-methylanthraquinone by nuclear magnetic resonance, infrared, and massanalysis. It was revealed that anthraquinone showed significantly increased elaboration of procollagen type I C-terminal pep-tide and glycosaminoglycans and reduced expression of the collagenase matrix metalloproteinase-1 dose-dependently in hu-man dermal fibroblasts. Furthermore, in a clinical trial, a nano-emulsion containing anthraquinone predominantly increasedthe dermal type I procollagen in nude mouse skin. These results suggest that anthraquinone derived from Noni extract is agood candidate for use as a new anti-wrinkle agent due to its strong induction of biosynthetic activity of extracellular matrixcomponents.

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