To investigate the role and contribution of extracellular calcium ion in submaxillary secretion and vasodilation in response to cholinergic stimulation, effects of calcium antagonists on submaxillary secretion and vasodilation induced by the chorda st...
To investigate the role and contribution of extracellular calcium ion in submaxillary secretion and vasodilation in response to cholinergic stimulation, effects of calcium antagonists on submaxillary secretion and vasodilation induced by the chorda stimulation at low frequency or by exogenously administered acetycholine/carbarchol were observed in chloralose-anesthetized cats.
Submaxillary secretion and blood flow increase reponses to the chorda tympani stimulation at low frequency(3V, 5㎐, 1ms) were markedly reduced by nifedipine or verapamil(2.9×10^-8mol/㎏). Also submaxillary secretion and blood flow increase responses to intraarterial Ach or carbachol(5.3×10^-8mol/㎏) was markedly attenuated by nifedipine.
These results suggest that extracellular calcium ion influx play a impatant role in salivary secretion and vasodilation.