Prognostic Factors for Improved Survival after Pulmonary Metastasectomy from Osteosarcoma

다국어 초록 (Multilingual Abstract)

Purpose: The aim of this study was to evaluate the clinical characteristics and chestcomputed tomography (CT) images of the patients who underwent pulmonary metastasectomyfrom osteosarcoma, and to identify the prognostic factors associatedwith the improvement of survival.
Materials and Methods: Fifty-nine patients with pulmonary metastases from osteosarcomawere included. The prognoses of the patients were assessed by 5-yearsurvival rate, after the pulmonary metastasectomy. The prognostic factors analyzedare as follows: age, sex, location of the primary osteosarcoma, disease-free interval(DFI) from the date of primary surgery to the date of pulmonary metastases on CT,number of pulmonary metastases, maximum diameter of largest pulmonary metastaticnodule, laterality (unilateral/bilateral), and location of pulmonary metastaticnodule(s). The log-rank test was used for univariate analyses, and the Cox proportionalhazards model was used for multivariate analyses.
Results: The 5-year survival rate was 33.89%. Multivariate analyses revealed that aDFI > 12 months [p = 0.041, hazard ratio = 0.504, 95% confidence interval (CI) =0.254--1.001] and nodule unilaterality (p = 0.029, hazard ratio = 0.291, 95% CI =0.096--0.883) were the independent prognostic factors affecting the 5-year survival.
The 5-year survival rates of patients with a DFI > 12 months and unilaterality ofthe metastatic nodule(s) increased to 44.11% and 39.28%, respectively.
Conclusion: The prognostic factors associated with the improved survival afterpulmonary metastasectomy from osteosarcoma were the DFI > 12 months and theunilaterality of the metastatic nodules.

참고문헌 (Reference)

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