이중기공 세포지지체 제작을 위한 powder extruder 개발

다국어 초록 (Multilingual Abstract)

Prior to our study, a novel technique was developed through combining SLUP(Salt Leaching Using Powder) and WNM(Wire-Network Molding) techniques to fabricate dual-pore scaffold. The advantages of this technique are solvent-free, high temperature-free, the pore interconnectivity and high porosity. Additionally, cell-proliferation(in vitro) of a dual-pore scaffold was faster than that of a scaffold fabricated by bio-plotting and SLUP technique. However these techniques have a disadvantage. For example, the scaffold fabrication process was manually. Therefore, it takes a long time and effort to make several scaffolds. In this study, we developed the powder extruder to fabricate dual-pore scaffold. The material was used for PCL(Polycaprolactone) and NaCl. The powder extruder was used as the basis for a 3D printer(Delta bot). The head of powder extruder was extruded using a screw. We compared characteristics of SLUP&WNM method with the powder extruder method for dual-pore scaffold fabrication