As increasing the demand for development of new drug, the synthesis of biologically active compounds play an important role in organic synthetic field. Because of inherent nature of enzyme and receptor in biological system, optical activity is essenti...
As increasing the demand for development of new drug, the synthesis of biologically active compounds play an important role in organic synthetic field. Because of inherent nature of enzyme and receptor in biological system, optical activity is essential for most of biologically active compounds to exert their biological activities.
This is the reason why we should synthesize the biologically active compound in the optically active form for meaningful studies on their physical or biological properties. In this sense, asymmetric synthesis is a powerful tool to provide us chiral synthons for organic synthesis as well as informations for biological studies on natural products. chiral enolates, active form of chiral kletones which were founded in many biological active compound as the essential pharmacophoric moiety, were pre-pared by multi-step methods, or in diastereoselective fashion, which needs to modificate the functional group, to attach chiral auxiliary that shall be removed after reaction.
Our project embrace the direct synthesis of chiral enolates from mesomeric ketones with chiral base to effect enantioselective deprotonation. We examined the additive effect on the asymmetric deprotonation using chiral base for the purposes of increasing the enantioselectivity and getting the available data concerning the mechanism of this reaction.