MIA-유도 골관절염 동물모델에서 hyaluronic acid 유도체와 인간 댓줄 유래 collagen 복합체가 골관절염 치료에 미치는 영향

다국어 초록 (Multilingual Abstract)

Osteoarthritis is a degenerative disease that is prevalent among the aged. It is characterized by
destruction and deformation of articular cartilage. In this study, we examined the effects of
hyaluronic acid derivative and human umbilical cord derived collagen complex on osteoarthritis in
MIA (monosodium iodoacetate) -induced osteoarthritis animal model. On the result of the
macroscopy, articular deformations of experimental groups were less than those of control groups.
Light microscopically, histological analysis(H&E stain, Alcian blue stain, Safranin 0 stain) showed
that cartilage-specific stain reaction was more prominent in experimental groups and the cartilage
destructions of experimental groups were less than those of control groups.
Immunohistochemically, positive reaction products of type II collagen were more prominent in the
surface of cartilage in the experimental groups. The results may be due to composition of the
injection which included extra cellular matrix and component of cartilage. The injection might
assist metabolism of chondrocyte and replenish the extra cellular matrix of cartilage. In
conclusion, hyaluronic acid derivative and human umbilical cord derived collagen complex showed
curative effects on osteoarthritis in MIA-induced osteoarthritis animal model. It might be considered as
component for development of intra-articular injections.