Biomaterials for the control of stem cell differentiation and cellular reprogramming = Biomaterials for the control of stem cell differentiation and cellular reprogramming

다국어 초록 (Multilingual Abstract)

Stem cell therapeutics have shown great potential for the treatment of incurable diseases, but their therapeutic efficacy needs to be improved by enhancing specific lineage differentiation for efficient tissue regeneration. Direct reprogramming has been highlighted for the generation of tissue-specific cell types, but low efficiency still remains a major challenge. In this presentation, several materials and devices will be introduced to promote neuronal differentiation of stem cells and direct conversion of skin fibroblasts to neuronal lineage cells. In the first part, microfluidic devices and nanoscale patterned substrates for the reconstitution of neural stem cell microenvironments are reported to promote functional neuronal differentiation. In the second part, micro-devices generating external stimulation and brain-specific microenvironment are reported for significantly improving the efficiency of polymer nanoparticle-mediated direct neural conversion.