The efficacy of medium-dose ultraviolet A-1 phototherapy on lichenoid purpura = The efficacy of medium-dose ultraviolet A-1 phototherapy on lichenoid purpura

다국어 초록 (Multilingual Abstract)

Background: Lichenoid purpura (LP) is a variant of pigmented purpuric dermatosis (PPD) that is characterized by rust macules or papules mainly on the legs and histologically by a dense, band-like dermal inflammatory cell infiltrate with extravasated red blood cells. Recent data suggests that LP may be a precursor of mycosis fungoides (MF), with similar histologic features. Medium-dose ultraviolet A-1 (UVA-1) is an effective treatment option for MF. From this perspective, medium-dose UVA-1 phototherapy may be an effective treatment for LP.
Objectives: To investigate the efficacy of medium-dose UVA-1 phototherapy on LP.
Methods: This study was conducted on 11 patients diagnosed with LP at one institution. Medium-dose (65J/㎠) regimens of UVA-1 were employed. The therapeutic efficacy was assessed according to the clinical examination before and after the last treatment.
Results: The patients were between 26 and 77 years of age with mean age of 49.1 years. All the patients developed gold to brownish papules, or plaques on the lower extremities and one patient also developed skin lesions on the abdomen. Among the 11 patients, two patients achieved complete remission and nine patients achieved partial remission. Mean numbers of irradiations of UVA-1 was 14.5 sessions, and no recurrence was observed during the mean follow-up period of 26.4 months.
Conclusion: Medium-dose UVA-1 phototherapy may be a safe and effective treatment modality for LP.