The release of H_2 receptor antagonist, Famotidine from cellulose matrices containing Hydroxypropylcellulose (HPC) in different ratios and types was studied.
The effects of tablet shape and compression pressure on dissolution rate were also studied. ...
The release of H_2 receptor antagonist, Famotidine from cellulose matrices containing Hydroxypropylcellulose (HPC) in different ratios and types was studied.
The effects of tablet shape and compression pressure on dissolution rate were also studied. And the effect of the pH of dissolution media was studied.
Increase in the ratio of polymer to drug has decreased the release rate. Increase of the polymer viscosity has decreased the release rate. The release rate of Famotidine was dependent on the pH of dissolution media, The release rate of drug was not much dependent on the compression pressure nut dependent the tablet shape and / or surface area.