Structural and Functional Stability of Biomolecules Based on Geumgang Ratio

다국어 초록 (Multilingual Abstract)

All natures and things of this world make a fixed ratio. Geumgang ratio, the iIndignous formative ratio of Korea is simple, stable, and practical as well as having aesthetic factors of golden ratio, so has been applied to design of building, work of art, and househld item, etc.
This study carried out to examine the distinctiveness based on an analysis on various cases of Geumgang ratio and to compare and analyze the link between molecular structure and function through a case study on Geumgang ratio discovered in biomolecular structure such as nucleic acid, protein, and ribonucleoprotein forming biosystem.
Geumgang ratio was found in ancient remains, traditional buildings, traditional furnitures and household Items in this country and in nature such as pruning of syconus and petal number of plants getting out of Fibonacci number. The ratio could be found in the biomolecular structure such as nucleic acid, zymoprotein and ribonucleoprotein.
Based on the results obtained in this study, it has been considered Geumgang ratio could be served for not only industrial design of commercial item but also the molecular design of new drug such as anticancer and biologically active agents.
In Advance, the more detailed researches on having visual data on the level of nanoscale using electron microscope(EM) or scanning tunneling microscope(STM) would be needed for the practical application to biomedical field.

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