정형의학적 측면에서의 근신경 검사법 = Orthopaedic Electordiagnosis on Nerve and Muscle

다국어 초록 (Multilingual Abstract)

It seems that a variety of muscular diseases result from the abnormal neuromuscular system, To understand the abnormal muscular mechanism, it is absolutely required to know in advance about the physiological and biochemical aspects relating to the contraction of muscular fibers, nerve action potential and neuromuscular transmission. It is not possible, of course, to understand all the biochemical and biophysical aspects concerning the creation and transmission of a nerve impulse. Many studies have been carried out since early studies done by Hodgkin (1951) and Hodgkin ＆ Huxley (1951). Like other somatic cells, neuromuscular cells has the environment of the intracellular fluid which is definitely different from the extracellular or interstitial fluid. While its intracellular component includes potassium (K), magnesium (Mg) and phosphorous (P), sodium calcium (Ca) and chloride (Cl) are the major ectracellular component, The intracellular ion concentration inside nerve muscle is kept within a narrow range by an electric and chemical energy which maintains the cellular wall balanced electrically and chemically ("stable wall potential"). It seems that these energies make the smooth neuromuscular action be accomplished by the pump function (sodium pump) which selectively pumps a variety of ions into cellular walls, as well as sodium within cells and, therefore, muscular action can be created. Although some basic studies have been performed on the mechanism of neuromuscular interaction, further studies are required to examine the mechanism leading to diagnosis in disease of nerve and muscle, abnormal syndrome, and their preventative measures.