Pathogenesis of Recalcitrant Chronic Rhinosinusitis: The Emerging Role of Innate Immune Cells

다국어 초록 (Multilingual Abstract)

Chronic rhinosinusitis (CRS) is a major part of the recalcitrant inflammatory diseases of the upper airway that needs enormous socioeconomic burden. T helper (Th) 2 type immune responses recruiting eosinophils were the most well-known immune players in CRS pathogenesis especially in western countries. By the piling up of a vast amount of researches to elucidate the pathogenic mechanism of CRS recently, heterogeneous inflammatory processes were found to be related to the phenotypes of CRS. Recently more cells other than T cells were in the focus of CRS pathogenesis, such as the epithelial cell, macrophage, innate lymphoid cells, and neutrophils. Here, we reviewed the recent research focusing on the innate immune cells related to CRS pathogenesis.

참고문헌 (Reference)

1 Geissmann F, "Unravelling mononuclear phagocyte heterogeneity" 10 : 453-460, 2010

2 Reh DD, "Treatment-recalcitrant chronic rhinosinusitis with polyps is associated with altered epithelial cell expression of interleukin-33" 24 : 105-109, 2010

3 Kabata H, "Thymic stromal lymphopoietin induces corticosteroid resistance in natural helper cells during airway inflammation" 4 : 2675-, 2013

4 Ziegler SF, "Thymic stromal lymphopoietin and allergic disease" 130 : 845-852, 2012

5 Mjosberg J, "The transcription factor GATA3 is essential for the function of human type 2 innate lymphoid cells" 37 : 649-659, 2012

6 Kim DW, "The status of the olfactory cleft may predict postoperative olfactory function in chronic rhinosinusitis with nasal polyposis" 25 : e90-e94, 2011

7 Kim DK, "The role of interleukin-33 in chronic rhinosinusitis" 72 : 635-645, 2017

8 Comeau MR, "The influence of TSLP on the allergic response" 3 : 138-147, 2010

9 Meng J, "The development of nasal polyp disease involves early nasal mucosal inflammation and remodelling" 8 : e82373-, 2013

10 Kouzaki H, "The danger signal, extracellular ATP, is a sensor for an airborne allergen and triggers IL-33 release and innate Th2-type responses" 186 : 4375-4387, 2011

11 Moussion C, "The IL-1-like cytokine IL-33 is constitutively expressed in the nucleus of endothelial cells and epithelial cells in vivo: a novel 'alarmin'?" 3 : e3331-, 2008

12 Ma Y, "Temporal neutrophil polarization following myocardial infarction" 110 : 51-61, 2016

13 Licona-Limon P, "TH2, allergy and group 2 innate lymphoid cells" 14 : 536-542, 2013

14 Blackwell DL, "Summary health statistics for U.S. adults: national health interview survey, 2012" 10 : 1-161, 2014

15 Chang JE, "Prostaglandin D2 regulates human type 2 innate lymphoid cell chemotaxis" 133 : 899-901, 2014

16 Xue L, "Prostaglandin D2 activates group 2 innate lymphoid cells through chemoattractant receptor-homologous molecule expressed on TH2 cells" 133 : 1184-1194, 2014

17 Lou H, "Predictive significance of tissue eosinophilia for nasal polyp recurrence in the Chinese population" 29 : 350-356, 2015

18 Bachert C, "Phenotypes and emerging endotypes of chronic rhinosinusitis" 4 : 621-628, 2016

19 Yamaguchi M, "PLA2G5 regulates transglutaminase activity of human IL-4-activated M2 macrophages through PGE2 generation" 100 : 131-141, 2016

20 Pothoven KL, "Oncostatin M promotes mucosal epithelial barrier dysfunction, and its expression is increased in patients with eosinophilic mucosal disease" 136 : 737-746, 2015

21 Murray PJ, "Obstacles and opportunities for understanding macrophage polarization" 89 : 557-563, 2011

22 Neill DR, "Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity" 464 : 1367-1370, 2010

23 Pothoven KL, "Neutrophils are a major source of the epithelial barrier disrupting cytokine oncostatin M in patients with mucosal airways disease" 139 : 1966-1978, 2017

24 Godin MS, "Nasal augmentation using Gore-Tex. A 10-year experience" 1 : 118-121, 1999

25 Cuartero MI, "N2 neutrophils, novel players in brain inflammation after stroke: modulation by the $PPAR{\gamma}$ agonist rosiglitazone" 44 : 3498-3508, 2013

26 Gordon S, "Monocyte and macrophage heterogeneity" 5 : 953-964, 2005

27 Sharkhuu T, "Mechanism of interleukin-25 (IL-17E)-induced pulmonary inflammation and airways hyper-reactivity" 36 : 1575-1583, 2006

28 Kim DK, "MBP-positive and CD11c-positive cells are associated with different phenotypes of Korean patients with non-asthmatic chronic rhinosinusitis" 9 : e111352-, 2014

29 Doherty TA, "Lung type 2 innate lymphoid cells express cysteinyl leukotriene receptor 1, which regulates TH2 cytokine production" 132 : 205-213, 2013

30 Byers DE, "Long-term IL-33-producing epithelial progenitor cells in chronic obstructive lung disease" 123 : 3967-3982, 2013

31 Lan F, "Interleukin-33 facilitates neutrophil recruitment and bacterial clearance in S. aureus-caused peritonitis" 72 : 74-80, 2016

32 Petersen BC, "Interleukin-25 induces type 2 cytokine production in a steroid-resistant interleukin-17RB+ myeloid population that exacerbates asthmatic pathology" 18 : 751-758, 2012

33 Kim HY, "Interleukin-17-producing innate lymphoid cells and the NLRP3 inflammasome facilitate obesityassociated airway hyperreactivity" 20 : 54-61, 2014

34 Liao B, "Interaction of thymic stromal lymphopoietin, IL-33, and their receptors in epithelial cells in eosinophilic chronic rhinosinusitis with nasal polyps" 70 : 1169-1180, 2015

35 Moro K, "Innate production of T(H)2 cytokines by adipose tissue-associated c-Kit(+)Sca-1(+) lymphoid cells" 463 : 540-544, 2010

36 Spits H, "Innate lymphoid cells--a proposal for uniform nomenclature" 13 : 145-149, 2013

37 Kim HY, "Innate lymphoid cells responding to IL-33 mediate airway hyperreactivity independently of adaptive immunity" 129 : 216-227, 2012

38 Chang YJ, "Innate lymphoid cells mediate influenza-induced airway hyper-reactivity independently of adaptive immunity" 12 : 631-638, 2011

39 Morita H, "Innate lymphoid cells in allergic and nonallergic inflammation" 138 : 1253-1264, 2016

40 Mahdavinia M, "Increased noneosinophilic nasal polyps in chronic rhinosinusitis in US second-generation Asians suggest genetic regulation of eosinophilia" 135 : 576-579, 2015

41 Wen W, "Increased neutrophilia in nasal polyps reduces the response to oral corticosteroid therapy" 129 : 1522-1528, 2012

42 Shikotra A, "Increased expression of immunoreactive thymic stromal lymphopoietin in patients with severe asthma" 129 : 104-111, 2012

43 Takabayashi T, "Increased expression of factor XIII-A in patients with chronic rhinosinusitis with nasal polyps" 132 : 584-592, 2013

44 Yao Y, "Increased expression of TIPE2 in alternatively activated macrophages is associated with eosinophilic inflammation and disease severity in chronic rhinosinusitis with nasal polyps" 7 : 963-972, 2017

45 Prefontaine D, "Increased IL-33 expression by epithelial cells in bronchial asthma" 125 : 752-754, 2010

46 Robinette ML, "Immune modules shared by innate lymphoid cells and T cells" 138 : 1243-1251, 2016

47 Cayrol C, "IL-33: an alarmin cytokine with crucial roles in innate immunity, inflammation and allergy" 31 : 31-37, 2014

48 Shaw JL, "IL-33-responsive innate lymphoid cells are an important source of IL-13 in chronic rhinosinusitis with nasal polyps" 188 : 432-439, 2013

49 Tjota MY, "IL-33-dependent induction of allergic lung inflammation by $Fc{\gamma}RIII$ signaling" 123 : 2287-2297, 2013

50 Hardman CS, "IL-33 citrine reporter mice reveal the temporal and spatial expression of IL-33 during allergic lung inflammation" 43 : 488-498, 2013

51 Fort MM, "IL-25 induces IL-4, IL-5, and IL-13 and Th2-associated pathologies in vivo" 15 : 985-995, 2001

52 Mizutani N, "IL-17A promotes the exacerbation of IL-33-induced airway hyperresponsiveness by enhancing neutrophilic inflammation via CXCR2 signaling in mice" 192 : 1372-1384, 2014

53 Mjosberg JM, "Human IL-25- and IL-33-responsive type 2 innate lymphoid cells are defined by expression of CRTH2 and CD161" 12 : 1055-1062, 2011

54 Ho J, "Group 2 innate lymphoid cells (ILC2s) are increased in chronic rhinosinusitis with nasal polyps or eosinophilia" 45 : 394-403, 2015

55 Takabayashi T, "Glandular mast cells with distinct phenotype are highly elevated in chronic rhinosinusitis with nasal polyps" 130 : 410-420, 2012

56 Iwakura Y, "Functional specialization of interleukin-17 family members" 34 : 149-162, 2011

57 Luzina IG, "Full-length IL-33 promotes inflammation but not Th2 response in vivo in an ST2-independent fashion" 189 : 403-410, 2012

58 Baba S, "Expression of IL-33 and its receptor ST2 in chronic rhinosinusitis with nasal polyps" 124 : E115-E122, 2014

59 Fokkens WJ, "European position paper on rhinosinusitis and nasal polyps 2012" 23 : 3-, 2012

60 Pichery M, "Endogenous IL-33 is highly expressed in mouse epithelial barrier tissues, lymphoid organs, brain, embryos, and inflamed tissues: in situ analysis using a novel Il-33-LacZ gene trap reporter strain" 188 : 3488-3495, 2012

61 김도현, "Effect of Chronic Rhinosinusitis With or Without Nasal Polyp on Quality of Life in South Korea: 5th Korea National Health and Nutrition Examination Survey Korean" 대한이비인후과학회 9 (9): 150-156, 2016

62 Fokkens WJ, "EPOS 2012: European position paper on rhinosinusitis and nasal polyps 2012. A summary for otorhinolaryngologists" 50 : 1-12, 2012

63 Wang X, "Diversity of TH cytokine profiles in patients with chronic rhinosinusitis: a multicenter study in Europe, Asia, and Oceania" 138 : 1344-1353, 2016

64 Cao PP, "Distinct immunopathologic characteristics of various types of chronic rhinosinusitis in adult Chinese" 124 : 478-484, 2009

65 Van Zele T, "Differentiation of chronic sinus diseases by measurement of inflammatory mediators" 61 : 1280-1289, 2006

66 Zhang N, "Different types of T-effector cells orchestrate mucosal inflammation in chronic sinus disease" 122 : 961-968, 2008

67 Kato A, "Dexamethasone and FK506 inhibit expression of distinct subsets of chemokines in human mast cells" 182 : 7233-7243, 2009

68 Yokota Y, "Development of peripheral lymphoid organs and natural killer cells depends on the helix-loop-helix inhibitor Id2" 397 : 702-706, 1999

69 Lam M, "Clinical severity and epithelial endotypes in chronic rhinosinusitis" 3 : 121-128, 2013

70 Huvenne W, "Chronic rhinosinusitis with and without nasal polyps: what is the difference?" 9 : 213-220, 2009

71 Ho J, "Cellular comparison of sinus mucosa vs polyp tissue from a single sinus cavity in chronic rhinosinusitis" 5 : 14-27, 2015

72 Townley RG, "CRTH2 antagonists in the treatment of allergic responses involving TH2 cells, basophils, and eosinophils" 109 : 365-374, 2012

73 Miljkovic D, "Association between group 2 innate lymphoid cells enrichment, nasal polyps and allergy in chronic rhinosinusitis" 69 : 1154-1161, 2014

74 Krysko O, "Alternatively activated macrophages and impaired phagocytosis of S. aureus in chronic rhinosinusitis" 66 : 396-403, 2011

75 Corrigan CJ, "Allergeninduced expression of IL-25 and IL-25 receptor in atopic asthmatic airways and late-phase cutaneous responses" 128 : 116-124, 2011

76 Weathington NM, "A novel peptide CXCR ligand derived from extracellular matrix degradation during airway inflammation" 12 : 317-323, 2006

77 Snelgrove RJ, "A critical role for LTA4H in limiting chronic pulmonary neutrophilic inflammation" 330 : 90-94, 2010