Hepatocellular Carcinoma Presenting as Uterine Metastasis = Hepatocellular Carcinoma Presenting as Uterine Metastasis

다국어 초록 (Multilingual Abstract)

Metastatic extragenital cancer that spreads to the uterus is rare. When it occurs, the extragenital primary disease is often in the breast or gastrointestinal tract. We report here on a case of hepatocellular carcinoma (HCC) that metastasis to the uterus. The patient was admitted for evaluation of a pelvic mass. The serum alpha-fetoprotein level was highly elevated. Magnetic resonance imaging of the abdomen and pelvis showed hepatic and uterine masses. The patient underwent surgical treatment. The histopathologic findings and immunohistochemical staining results of the uterine mass were char acteristics of metastatic HCC. The endometrium and both ovaries were free of tumor. Up to now, there have been only two cases of uterine metastasis from HCC reported in the English literature. This case is the first documented instance of a metastatic uterine tumor from HCC that spared both ovaries.

참고문헌 (Reference)

1 Ryo E., "Uterine metastasis from hepatocellular carcinoma: a case report" 16 : 1894-6, 2006

2 Spatz A., "Primary yolk sac tumor of the endometrium: a case report and review of the literature" 70 : 285-8, 1998

3 Yeu-Tsu ML, "Primary liver cancer: pattern of metastases" 36 : 26-31, 1987

4 Okuda K., "Natural history of hepatocellular carcinoma and prognosis in relation to treatment: study of 850 patients" 56 : 918-28, 1985

5 Charache H., "Metastatic carcinoma in the uterus" 53 : 152-7, 1941

6 Kumar NB, "Metastases to the uterine corpus from extragenital cancers. A clinicopathologic study of 63 cases" 50 : 2163-9, 1982

7 Mazur MT, "Metastases to the female genital tract" 53 : 1978-84, 1984

8 Legg JW, "Melanotic sarcoma of the eyeball: secondary growths in the organs of the chest and belly, particularly in the liver" 29 : 225-30, 1878

9 Takano M., "Malignant mixed Mullerian tumor of the uterine corpus with alphafetoprotein producing hepatoid adenocarcinoma component" 91 : 444-8, 2003

10 Stemmermann GN, "Extrapelvic carcinoma metastatic to the uterus" 82 : 1261-6, 1961

11 Katyal S., "Extrahepatic metastases of hepatocellular carcinoma" 216 : 698-703, 2000

12 Adams SF, "An alpha fetoprotein-producing hepatoid adenocarcinoma of the endometrium" 83 : 418-21, 2001

13 Kubo K., "Alpha-fetoprotein producing papillary adenocarcinoma originating from a uterine body" 41 : 399-403, 1991