마이코플라스마 폐렴에서 혈장 내 성장인자들의 상 = Increased Growth Factors in Children with Mycoplasma pneumoniae Pneumonia

국문 초록 (Abstract)

목 적:본 연구에서 저자들은 마이코플라스마에 의한 급성 폐렴으로 입원하였던 소아들을 대상으로 기도의 섬유화 현상과 개형에 관여하는 것으로 알려진 TGF-β1 및 PDGF-BB와 같은 성장인자들이 증가되어 있는지와 이들이 임상 양상에 따라 어떤 차이를 보이는지 알아보고자 하였다.
방 법:2006년 8월부터 2008년 2월까지 마이코플라스마 폐렴으로 입원한 환아 52명을 대상으로 잦은 천명 증상을 보인 천명군과 이전에 천명의 병력이 없었던 비천명군으로 분류하였다. 천명군은 입원 이전에 3번 이상의 반복적인 천명의 병력이 있었던 환아들로 정의하였다. 경미한 수술을 위해 입원한 15명의 환아를 대조군으로 선정하여 함께 조사하였다. ELISA 로 TGF-β1 및 PDGF-BB를 측정하였고 이들이 마이코플라스마 감염동안에 증가하는지, 환아들의 임상 양상에 따라 어떤 차이를 보이는지를 조사하였다.
결 과:TGF-β1 및 PDGF-BB는 대조군에 비하여 마이코플라스마 폐렴 환아에서 의미있게 증가되어 있었으며, 천명군에서 비천명군에 비해 증가되어 있었으나, 통계학적 유의성은 없었다. 천명군 내에서 TGF-β1은 아토피 환자에서 비아토피군에 비해 의미있게 증가되어 있었다.
결 론:본 연구에서는 마이코플라스마 폐렴으로 입원한 어린 소아들에서 TGF-β1 및 PDGF-BB 등의 성장 인자들이 의미있게 증가된다는 것을 보여 주며, 이들이 마이코플라스마에 의한 하부기도 감염의 병태생리학적 기전에서 중요한 역할을 한다는 것을 시사하는 것으로 생각되었다.

다국어 초록 (Multilingual Abstract)

Purpose:Mycoplasma pneumoniae is a common causative agent of community acquired pneumonia in children and is well known to cause various respiratory and extrapulmonary diseases. We determined whether growth factors, including transforming growth factor (TGF)-β1 and platelet-derived growth factor (PDGF-BB) that regulate airway fibrosis and remodeling, are increased in young children with M. pneumoniae pneumonia and also investigated if there was any difference in relation to the clinical status of the patients.
Methods:Fifty-two patients (3 to 6 years of age) who were admitted with M. pneumoniae pneumonia were enrolled and divided into 2 groups: the patients with frequent wheezing episodes (group A, n=28) and the patients with no previous history of wheeze (group B, n=24). The former group included the patients who had recurrent wheeze more than 3 times before admission. Fifteen children admitted with minor surgical problems were also studied as controls. TGF-β1 and PDGF-BB were measured in the plasma samples collected on admission using ELISA in both patient groups and controls.
Results:Plasma TGF-β1 and PDGF-BB levels were increased significantly in the patients with M. pneumoniae pneumonia as compared to the controls (P＜0.01, respectively). TGF-β1 and PDGF-BB were higher in group A than in group B, but the difference was not statistically significant (P=0.08 vs. P=0.05). In group A, TGF-β1 was significantly higher in atopic patients than in non-atopic patients (P＜0.05).
Conclusion:Our study showed significantly increased TGF-β1 and PDGF-BB in patients with M. pneumoniae pneumonia. It is suggested that these growth factors may play an important role in the pathogenesis of lower airway infection by M. pneumoniae.

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