The Effects of Hominis Placenta Hydrate (HPH) on the Bone Marrow Failure Induced by 5-Fluorouracil

다국어 초록 (Multilingual Abstract)

Aim: To examine the efficacy of Hominis Placenta Hydrate (HPH) on the hemopoiesis in a myelosuppression model system. Methods: Mice were injected with 5-Fluorouracil (5-FU) intraperitoneally and were administered with 200 mg/kg and 1000 mg/kg of HPH. Peripheral blood was analyzed at 5, 9, and 13 days. Histopathologic examination of bone marrow was performed at 5 days after 5-FU injection. The expression of cytokine involved in hemopoiesis was examined by using ELISA kit. Results: The hematology data demonstrated that the treatment of all the agents augmented monocytes and leucocytes counts in the peripheral blood WBC and platelet in HPH treated group were significant increased compared with control group. Also, cell numbers of RBC and Hb were restored. In HPH treated group, expression of IL-3, GM-CSF was significant increased But not TPO. Conclusions: Based on the above results, it is suggested that Hominis Placenta Hydrate is an effective remedy for the bone marrow failure and myelosuppression occurring during chemotherapy

참고문헌 (Reference)

1 "supports the growth of human multipotential progenitor cells with a high replating potential" 2216-21,

2 "Thrombopoietin accelerates platelet red blood cell and neutrophil recovery in myelosuppressed mice" 24 : 1238-1246, 1996

3 "The study on the Hominis Placenta Aqua acupuncture solution" 17 : 67-74, 2000

4 "The effects of Saenghyuldan on the bone marrow failure" 22 : 33-45, 2001

5 "Stem cell factor directly stimulate the development of enriched granulocyte macrophage colony forming cells and promotes the effects of other colony stimulating factors" 2230-6,

6 "Simultaneous administration of TPO and G CSF after cytoreductive treatment of rhesus monkeysprevents thrombocytopenia accelerates platelet and red cell reconstitution alleviates neutropenia and promotes the recovery of immature bone marrow cells" 25 : 1084-1093, 1997

7 "Signal Transduction Multiple pathways multiple options for therapy" 19 : 295-303, 2001

8 "Self renewal differentiation or death regulation and manipulation of hematopoietic stem cell fate" 5 : 201-208, 1995

9 "Recombinant human interleukin1 receptor antagonist protects early myeloid progenitors in a murine model of cyclophosphamide induced myelotoxicity" 85 : 2393-2401, 1995

10 "Preventive effects of Hominis Placenta Extract on H2O2 Induced Apoptosis in Pineal Gland Cell Line" 18 : 69-78, 2001

11 "Oxford textbook of oncology" Oxford University Press Inc 4 : 445-453, 1995

12 "Modulation of magakaryocytopoiesis by thrombopoietin The c mpl ligand" 86 : 1331-1338, 1995

13 "MedicalImmunology" Simon & Schuster Company New jersey 9 : 146-167, 1997

14 "Immunology" Mosby International Ltd 5 : 155-169, 1998

15 "Hematopoietic stem cells for transplantation" 3 : 314-317, 2002

16 "Hematopoietic stem cell depletion by restorative growth factor regimens during repeated high-dose cyclophosphamide therapy" 77-83,

17 "Hematopoietic stem cell deficit of transplanted bone marrow previously exposed to cytotoxic agents" 438-43, exphematol1993

18 "Hematopoietic stem cell" 34 : 65-76, 2002

19 "Granulocyte macrophage colony stimulating factor GM CSF priming of high dose etoposide and cyclophosphamide A pilot trial" 24 : 1363-1368, 1996

20 "Granulocyte colony stimulating factor impedes recovery from damage caused by cytotoxic agents through increased differentiation at the expense of self renewal" 18 : 120-127, 2000

21 "Graham Homing and mobilization in the stem cell niche" 9 : 233-238, 1999

22 "Embryonic stem cell and nuclear transfer" 34 : 41-52, 2002

23 "Effects of Placenta Hominis on the sex hormon content and lipid content in the ovariectomized rats" 14 : 103-117, 2001

24 "Effect of c-kit ligand on in vivo human megakaryocytopoiesis" 2854-9,

25 "Effect of Hominis Placenta on the ovariectomised osteoporotic rats" 16 : 213-221, 1999

26 "Cytokine manipulation of primitive human hematopoietic cell self renewal" 94 : 4698-4703, 1997

27 "Cyclophosphamide granulocyte colony stimulating factor induce hematopoietic stem cells to proliferate prior to mobilizatio" 94 : 1908-1913, 1996

28 "Current trends of stem cell research using pluripotent stem Cells" 34 : 7-21, 2002

29 "Bone marrow stem cell protection from chemotherapy by low molecular weight compounds" 29 : 123-137, 2001

30 "Accelerated recovery from cyclophosphamide induced leukopenia in mice administered a Japanese ethical herbal drug Hochu ekkii to" 44 : 223-231, 1999