치아의 맹출 과정과 치간이개로 유도된 치아 및 치조골의 흡수 과정에서 치주인대 세포와 치주인대 단백질의 기능을 알아보기 위하여, 발육 중인 흰쥐를 치근 형성 전, 치근 형성 시작과 치...
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https://www.riss.kr/link?id=A105534805
2004
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치주인대 ; 치간이개 ; PDLs22 ; RANKL ; OPG ; Periodontal ligament ; Interdental separation
515
KCI등재후보,SCOPUS,SCIE
학술저널
71-81(11쪽)
1
학회 요청에 의해 무료로 제공
0
상세조회0
다운로드국문 초록 (Abstract)
치아의 맹출 과정과 치간이개로 유도된 치아 및 치조골의 흡수 과정에서 치주인대 세포와 치주인대 단백질의 기능을 알아보기 위하여, 발육 중인 흰쥐를 치근 형성 전, 치근 형성 시작과 치...
치아의 맹출 과정과 치간이개로 유도된 치아 및 치조골의 흡수 과정에서 치주인대 세포와 치주인대 단백질의 기능을 알아보기 위하여, 발육 중인 흰쥐를 치근 형성 전, 치근 형성 시작과 치근 형성 및 맹출 시기로 구분하여 표본을 제작하고, 또한 성장 중인 흰쥐를 2주간 치간 이개시켜 조직표본을 제작하였다. 치주인대 섬유모세포에서 특이적으로 발현되며 치주인대의 분화와 성숙에 관여하는 PDLs22 단백질과 치아와 치조골의 파괴와 흡수를 조절하는 것으로 알려진 RANKL과 OPG의 발현을 면역 조직화학적으로 연구하였다. PDLs22 단백질은 치근 형성이 시작되면서부터 치낭세포와 골모세포에서 발현되어, 치아가 맹출하는 과정에서도 그 발현이 계속 유지되었으나, 치간이개에 의하여 치주인대가 개조되는 부위에서는 발현이 감소하였다. RANKL은 치근 형성 과정에서는 미약한 발현을 나타내었으나, 치아가 맹출하면서 발현이 증대되었으며, 치간이개에 의한 치근과 치조골 흡수과정에서는 치주인대세포, 골모세포, 치수세포 및 파치세포에서 발현이 증대 되었다. OPG는 치근이 형성되는 시기에는 강한 발현을 보였으나, 치아가 맹출하면서 발현이 현저히 감소하였ㄱ, 치아와 치조골의 흡수가 진행됨에 따라서 발현이 다소 감소하였다.
다국어 초록 (Multilingual Abstract)
In this study, we attempt to investigate the mechanisms by which PDL cells regulate osteoclast formation and also tc know whether PDL retained their characteristic phenotype during tooth eruption and interdental separation. Rats were prepared at devel...
In this study, we attempt to investigate the mechanisms by which PDL cells regulate osteoclast formation and also tc know whether PDL retained their characteristic phenotype during tooth eruption and interdental separation. Rats were prepared at developmental days 21 (pre-root formation), 27 (root development), 34 (advanced root formation/ eruption) and at later times(adult rats). To induce severe resorption state of alveolar bone and tooth root, interdental separation with brass wire was performed between the lower first and second molars for 2 weeks in adult rats. Rat mandibles were dernineralized and embedded in paraffin, and horizontal and frontal section were prepared for immunohistochenucal analysis using PDL-specific protein 22 (PDLs22), receptor activator of NFKB ligand (RANKL) and ostei protegerin (OPG) antibodies. 1. Root formation and eruption stage of tooth development. 1) PDLs22 immunolocalization was observed in tooth folliclelPDL cells and osteoblasts throught out the root formation and eruption stages of tooth development 2) RANKL expression became stronger at eruption stage than root formation stage of tooth development. 3) Strong expression of OPG was detected in follice/PDL cells of root formation stage but it was decreased with tooth eruption. 2. Interdental separation between lower first and second molar. 1) Con parared to normal animal, multinucleated osteoclasts and odontoclasts were markedly induced in the alveolar bone and tooth root with PDL remodeling in hematoxylin-eosin section. 2) PDLs22 expression was decreased with interdental separation. 3) RANKL expression was increased with interdental separation in PDL fibroblasts, osteoblasts, odontoclasts and it lacunae, resorbing dentin, cementum and bone matrix. 4) OPG expression was slightly decreased in the PDL cells adjacent to the alveolar bone and root surface with interdental separation. These results suggested that during tooth eruption and tooth movement, RANKL and OPG in the periodontal tissues are important determinants regulating balanced alveolar bone and tooth root resorption. And it is also suggested that PDL cells retained their characteristic phenotype during tooth eruption and interdental separation except for the short period of PDL remodeling.
참고문헌 (Reference)
1 "발생중인 생쥐 치아 및 치주조직에서 치주인대-특이 단백질: PDLs22의 발현" 32 : 1-12, 2002
2 "Tooth movement and changes in periodontal tissue in response to orthodontic force in rats vary depending on the time of day the force is applied" 23 : 329-338, 2001
3 "Regulation of receptor activator of nuclear factor -kB ligand and osteoprotegerin mRNA expression by parathyroid hormone is predominantly mediated by the protein kinase a pathway in murine bone marrow cultures" 31 : 252-259, 2002
4 "Regulation of osteoclast differentiation and function by receptor activator of NFkB ligand and osteoprotegerin" 268 : 137-146, 2002
5 "Production of matrix-degrading enzymes and inhibition of osteoclast-like cell differentiation by fibroblast-like cells from the periodontal ligament of human primary teeth" 78 : 681-689, 1999
6 "Periodontal ligament cells under mechanical stress induce osteoclastogenesis by receptor activator of nuclear factor kB liagand up-regulation via prostaglandin E2 Synthesis" 17 : 210-220, 2002
7 "Osteoclast recruitment to sites of compression in orthodontic tooth movement" 120 : 477-489, 2001
8 "Osteoclast induction in periodontal tissue during experimental movement of incisors in osteoprotegerin-deficient mice" 266 : 218-225, 2002
9 "OPGL is a key regulator of osteoclastogenesis, lympocyte development and lymph-node organogenesis" 397 : 315-323, 1999
10 "Nuclear localization of type I parathyroid hormone/parathyroid hormone-related protein receptors in deer antler osteoclasts: evidence for parathyroid hormone-related protein and receptor activator NF-kappaB-dependent effects on osteoclast formation in regenerating mammalian bone" 17 : 455-464, 2002
1 "발생중인 생쥐 치아 및 치주조직에서 치주인대-특이 단백질: PDLs22의 발현" 32 : 1-12, 2002
2 "Tooth movement and changes in periodontal tissue in response to orthodontic force in rats vary depending on the time of day the force is applied" 23 : 329-338, 2001
3 "Regulation of receptor activator of nuclear factor -kB ligand and osteoprotegerin mRNA expression by parathyroid hormone is predominantly mediated by the protein kinase a pathway in murine bone marrow cultures" 31 : 252-259, 2002
4 "Regulation of osteoclast differentiation and function by receptor activator of NFkB ligand and osteoprotegerin" 268 : 137-146, 2002
5 "Production of matrix-degrading enzymes and inhibition of osteoclast-like cell differentiation by fibroblast-like cells from the periodontal ligament of human primary teeth" 78 : 681-689, 1999
6 "Periodontal ligament cells under mechanical stress induce osteoclastogenesis by receptor activator of nuclear factor kB liagand up-regulation via prostaglandin E2 Synthesis" 17 : 210-220, 2002
7 "Osteoclast recruitment to sites of compression in orthodontic tooth movement" 120 : 477-489, 2001
8 "Osteoclast induction in periodontal tissue during experimental movement of incisors in osteoprotegerin-deficient mice" 266 : 218-225, 2002
9 "OPGL is a key regulator of osteoclastogenesis, lympocyte development and lymph-node organogenesis" 397 : 315-323, 1999
10 "Nuclear localization of type I parathyroid hormone/parathyroid hormone-related protein receptors in deer antler osteoclasts: evidence for parathyroid hormone-related protein and receptor activator NF-kappaB-dependent effects on osteoclast formation in regenerating mammalian bone" 17 : 455-464, 2002
11 "Morphological changes in periodontal mechanoreceptors of mouse maxillary incisors after the experimental induction of anterior crossbite a light and electron microscopic observation using immunohistochemistry for PGP 9" 21 : 15-29, 1999
12 "Localization of receptor activator of NFkB ligand, RANKL, in periodontal tissues during experimental movement of rat molars" 50 : 365-369, 2001
13 "Localization of RANKL mRNA and protein in skeletal and extraskeletal tissues" 25 : 525-534, 1999
14 "Isolation and characterization of cultured human periodontal ligament fibroblast-specific cDNAs" 282 : 1145-1153, 2001
15 "Inhibition of osteoclastogenesis by the secretion of osteoprotegerin in vitro by rat dental follicle cells and its implications for tooth eruption" 47 (47): 247-254, 2002
16 "Immunolocalization of vacuolar-type H+-ATPase,cathepsin K, matrix mettalloproteinase-9, and receptor activator of NFkB ligand in odontoclasts during physiological root resorption of human deciduous teeth" 264 : 305-311, 2001
17 "Immunolocalization of osteoclast differentiation factor in rat periodontium" 47 : 55-58, 2002
18 "Immunohistochemical localization of receptor activator of nuclear factor kappaB (RANK) and its ligand (RANKL) in human deciduous teeth" 1 : 45-52, 2002
19 "Identification and characterization of a novel protein, periostin, with restricted expression of periosteum and periodontal ligament increased expression by transforming growth factor β" 14 : 1239-1249, 1999
20 "Human periodontal ligament cell derived from deciduous teeth induce osteoclastogenesis in vitro" 34 : 44-51, 2002
21 "Force-induced osteoclast apoptosis in vivo is accompanied by elevation in transforming growth factor β and osteoprotegerin expression" 15 : 1924-1934, 2000
22 "Extracellular role of 100A4 calium-binding protein in the periodontal ligament" 255 : 416-420, 1999
23 "Expression of type I and XII collagen during development of the periodontal ligament in the mouse" 43 : 779-787, 1998
24 "Expression of specific gene transcripts in periodontal ligament fibroblast" 23 : 1-13, 1999
25 "Dual regulation of osteoclast differentiation by periodontal ligament cells through RANKL stimulation and OPG inhibition" 80 : 887-891, 2001
26 "Dental cell express factors that regulate bone resorption" 3 : 145-152, 2000
27 "Cyclic adenosine monophosphate/ protein kinase a mediates parathyroid hormone/parathyroid hormone related protein receptor regulation of osteoclastogenesis and expression of RANKL and osteoprotegerin mRNAs by marrow stromal cells" 17 : 1667-1679, 2002
28 "Characterization of the bone-resorptive effect of interleukin-11 in cultured mouse calvarial bones" 31 : 242-251, 2002
29 "Cellular, molecular, and genetic determinants of tooth eruption" 13 : 323-334, 2002
미니스크류 식립 부위로서 정중 구개봉합부 골의 두께에 관한 연구
구조적 대응체 분석법에 의한 골격성 Ⅱ급 부정교합 환자의 악교정 수술전후의 비교
상악전치 후방 견인시 견인 loop 후방에 부여한 gable bend 양에 따른 치아이동 양상에 관한 연구
학술지 이력
연월일 | 이력구분 | 이력상세 | 등재구분 |
---|---|---|---|
2023 | 평가예정 | 해외DB학술지평가 신청대상 (해외등재 학술지 평가) | |
2020-01-01 | 평가 | 등재학술지 유지 (해외등재 학술지 평가) | ![]() |
2010-01-01 | 평가 | 등재학술지 유지 (등재유지) | ![]() |
2008-01-01 | 평가 | 등재학술지 유지 (등재유지) | ![]() |
2005-01-01 | 평가 | 등재학술지 선정 (등재후보2차) | ![]() |
2004-01-01 | 평가 | 등재후보 1차 PASS (등재후보1차) | ![]() |
2003-01-01 | 평가 | 등재후보학술지 유지 (등재후보1차) | ![]() |
2002-01-01 | 평가 | 등재후보학술지 유지 (등재후보1차) | ![]() |
2000-07-01 | 평가 | 등재후보학술지 선정 (신규평가) | ![]() |
학술지 인용정보
기준연도 | WOS-KCI 통합IF(2년) | KCIF(2년) | KCIF(3년) |
---|---|---|---|
2016 | 1.13 | 0.47 | 0.83 |
KCIF(4년) | KCIF(5년) | 중심성지수(3년) | 즉시성지수 |
0.67 | 0.55 | 0.311 | 0.24 |