출혈성 쇼크모델에서의 골수강내 주사에 의한 수액소생술의 효과 = EFFECT OF INTRAOSSEOUS INFUSION IN FLUID RESUSCITATION OF RABBIT HEMORRHAGIC SHOCK MODEL

다국어 초록 (Multilingual Abstract)

We studied the clinical applicability of intraosseous route as a rapidly, easily obt.ainable venous access route in shock resuscitation using rabbit hemorrhagic shock model. The exper iment was conducted after induction of shock by withdrawing one-third of blood volume. In the 1st experiment. Three tirnes of shed blood was replaced with saline solution in intraosseous and in- travenous group but no fluid was given to control group. The mean art.erial pressure and hema- tocr it were observed throughout the experiment. In the 2nd experiment, t,he flow rate between gravity and 150 mmHg-pressurized intraosseous infusion was compared.
The results were as follows : In the 1st experiment,, all t,hree groups showed a drop in MAP to at least 40% of the baseline value after induction of hemorrhage. At 5min after beginning of fluid administration, the MAP was elevated to 105% and 100% of baseline in the intraosseous and intravenous group, respectively. After fluid infusion was finished, MAP declined in both groups but intravenous group showed marked drop and maintained lower value than control group until t,he end of experiment. In the 2nd experiment, the flow rat.e was 3.8ml/min by gravity and 4.8ml/rnin by 150mmHg pressure and showed no statistical difference.
In conclusion, t.he intraosseous infusion showed superior effect, in restoring and maintaining art,erial pressure than conventional intraveous infusion in the initial fluid resuscitation of rabbit, shock model.