과배란유도와 동결보존배아를 이용한 체외수정시술에서 난관수종이 임신율에 미치는 영향에 관한 연구 = Effect of Hydrosalpinx on IVF Outcome in Controlled Ovarian Hyperstimulation Cycles and Cryopreserved Embryo Transfer Cycles

다국어 초록 (Multilingual Abstract)

This study was performed to determine the effect of hydrosalpinx on the outcome with in vitro fertilization and embryo transfer(IVF-ET). Hydrosalpingeal fluid may leak into the uterine cavity during or after ovarian hyperstimulation and can cause deletorious effect on embryo or implantation. Herein, we reported the effect of hydrosalpinx on the cycle outcome of IVF in controlled ovarian hyperstimulation cycles and cryopreserved-thawed embryo transfer cycles. In controlled ovarian hyperstimulation cycles, comparisons were made between 59 IVF cycles of 54 patients having tubal disease without hydrosalpinx(control group) and 36 IVF cycles of 35 patients carrying hydrosalpinx(hydrosalpinx group). Both clinical pregnancy and implantation rates were significantly lower in hydrosalpinx group(25.4 versus 8.3%, and 11.6 versus 2.0% respectively). Four ectopic pregnancies were noted in hydrosalpinx group compared to one in the control group. In cryopreserved-thawed embryo transfer cycles, comparisons were made between 27 IVF cycles of 25 patients having tubal disease without hydrosalpinx(control group) and 13 IVF cycles of 13 patients carrying hydrosalpinx(hydrosalpinx group). There was a tendency of decreased pregnancy and implantation rates in hydrosalpinx group compared to the control (37.0 versus 15.4%, and 9.9% versus 4.0% respectively). One ectopic pregnancy was noted in the hydrosalpinx group compared to none in the control group. These data indicate that the presence of hydrosalpinx may negatively affect IVF outcome. We suggest that patients presenting with hydrosalpinx should consider surgical correction to optimize their outcome with IVF procedure.