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KCIBackground : A point mutation in the RET proto-oncogene, in medullary thyroid carcinoma (MTC) is well known, but no other genetic causes of MTC have been found. This study was performed to identify the most common DNA copy number changes in MTC by com...
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RISS 인기검색어
DNA Copy Number Changes in Thyroid Medullary Carcinomas Determined by Comparative Genomic Hybridization
한글로보기https://www.riss.kr/link?id=A101633362
- 저자
- 발행기관
- 학술지명
- 권호사항
-
발행연도
2008
-
작성언어
English
- 주제어
-
등재정보
KCI등재
-
자료형태
학술저널
- 발행기관 URL
-
수록면
27-32(6쪽)
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KCI 피인용횟수
0
- 제공처
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상세조회 -
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다운로드
부가정보
다국어 초록 (Multilingual Abstract)
Background : A point mutation in the RET proto-oncogene, in medullary thyroid carcinoma
(MTC) is well known, but no other genetic causes of MTC have been found. This study was
performed to identify the most common DNA copy number changes in MTC by comparative
genomic hybridization (CGH). Methods : Twenty-nine surgically resected MTC specimens
were retrospectively selected from patients operated on between 1996 and 2004 at the Asan
Medical Center. A review of the clinical data and pathological findings was performed. Congored
staining and immunohistochemical stains (calcitonin, chromogranin A and CEA) were
processed by tissue microarray. CGH analysis was performed. Results : The Congo-red stain
was positive in only 12 cases. The immunohistochemical results were positive in 29 cases
for chromogranin A, 26 cases for CEA and 25 cases for calcitonin. DNA copy number changes
were found in 23 cases (79.3%). The most frequent change was a gain of 19q (65.5%); less
frequent changes were gain of 22 (55.2%), 19p (51.7%), 16p (27.58%), 17q (17.24%), and
loss of 4q (27.6%) and 3p (17.24%). Conclusions : DNA copy number changes of MTC were
more common (79.3%) than reported in previous studies. The most frequent changes were
gains in 19q, 22 and 19p.
(MTC) is well known, but no other genetic causes of MTC have been found. This study was
performed to identify the most common DNA copy number changes in MTC by comparative
genomic hybridization (CGH). Methods : Twenty-nine surgically resected MTC specimens
were retrospectively selected from patients operated on between 1996 and 2004 at the Asan
Medical Center. A review of the clinical data and pathological findings was performed. Congored
staining and immunohistochemical stains (calcitonin, chromogranin A and CEA) were
processed by tissue microarray. CGH analysis was performed. Results : The Congo-red stain
was positive in only 12 cases. The immunohistochemical results were positive in 29 cases
for chromogranin A, 26 cases for CEA and 25 cases for calcitonin. DNA copy number changes
were found in 23 cases (79.3%). The most frequent change was a gain of 19q (65.5%); less
frequent changes were gain of 22 (55.2%), 19p (51.7%), 16p (27.58%), 17q (17.24%), and
loss of 4q (27.6%) and 3p (17.24%). Conclusions : DNA copy number changes of MTC were
more common (79.3%) than reported in previous studies. The most frequent changes were
gains in 19q, 22 and 19p.
Background : A point mutation in the RET proto-oncogene, in medullary thyroid carcinoma
(MTC) is well known, but no other genetic causes of MTC have been found. This study was
performed to identify the most common DNA copy number changes in MTC by comparative
genomic hybridization (CGH). Methods : Twenty-nine surgically resected MTC specimens
were retrospectively selected from patients operated on between 1996 and 2004 at the Asan
Medical Center. A review of the clinical data and pathological findings was performed. Congored
staining and immunohistochemical stains (calcitonin, chromogranin A and CEA) were
processed by tissue microarray. CGH analysis was performed. Results : The Congo-red stain
was positive in only 12 cases. The immunohistochemical results were positive in 29 cases
for chromogranin A, 26 cases for CEA and 25 cases for calcitonin. DNA copy number changes
were found in 23 cases (79.3%). The most frequent change was a gain of 19q (65.5%); less
frequent changes were gain of 22 (55.2%), 19p (51.7%), 16p (27.58%), 17q (17.24%), and
loss of 4q (27.6%) and 3p (17.24%). Conclusions : DNA copy number changes of MTC were
more common (79.3%) than reported in previous studies. The most frequent changes were
gains in 19q, 22 and 19p.
다국어 초록 (Multilingual Abstract)
Background : A point mutation in the RET proto-oncogene, in medullary thyroid carcinoma
(MTC) is well known, but no other genetic causes of MTC have been found. This study was
performed to identify the most common DNA copy number changes in MTC by comparative
genomic hybridization (CGH). Methods : Twenty-nine surgically resected MTC specimens
were retrospectively selected from patients operated on between 1996 and 2004 at the Asan
Medical Center. A review of the clinical data and pathological findings was performed. Congored
staining and immunohistochemical stains (calcitonin, chromogranin A and CEA) were
processed by tissue microarray. CGH analysis was performed. Results : The Congo-red stain
was positive in only 12 cases. The immunohistochemical results were positive in 29 cases
for chromogranin A, 26 cases for CEA and 25 cases for calcitonin. DNA copy number changes
were found in 23 cases (79.3%). The most frequent change was a gain of 19q (65.5%); less
frequent changes were gain of 22 (55.2%), 19p (51.7%), 16p (27.58%), 17q (17.24%), and
loss of 4q (27.6%) and 3p (17.24%). Conclusions : DNA copy number changes of MTC were
more common (79.3%) than reported in previous studies. The most frequent changes were
gains in 19q, 22 and 19p.
(MTC) is well known, but no other genetic causes of MTC have been found. This study was
performed to identify the most common DNA copy number changes in MTC by comparative
genomic hybridization (CGH). Methods : Twenty-nine surgically resected MTC specimens
were retrospectively selected from patients operated on between 1996 and 2004 at the Asan
Medical Center. A review of the clinical data and pathological findings was performed. Congored
staining and immunohistochemical stains (calcitonin, chromogranin A and CEA) were
processed by tissue microarray. CGH analysis was performed. Results : The Congo-red stain
was positive in only 12 cases. The immunohistochemical results were positive in 29 cases
for chromogranin A, 26 cases for CEA and 25 cases for calcitonin. DNA copy number changes
were found in 23 cases (79.3%). The most frequent change was a gain of 19q (65.5%); less
frequent changes were gain of 22 (55.2%), 19p (51.7%), 16p (27.58%), 17q (17.24%), and
loss of 4q (27.6%) and 3p (17.24%). Conclusions : DNA copy number changes of MTC were
more common (79.3%) than reported in previous studies. The most frequent changes were
gains in 19q, 22 and 19p.
Background : A point mutation in the RET proto-oncogene, in medullary thyroid carcinoma (MTC) is well known, but no other genetic causes of MTC have been found. This study was performed to identify the most common DNA copy number changes in MTC by c...
Background : A point mutation in the RET proto-oncogene, in medullary thyroid carcinoma
(MTC) is well known, but no other genetic causes of MTC have been found. This study was
performed to identify the most common DNA copy number changes in MTC by comparative
genomic hybridization (CGH). Methods : Twenty-nine surgically resected MTC specimens
were retrospectively selected from patients operated on between 1996 and 2004 at the Asan
Medical Center. A review of the clinical data and pathological findings was performed. Congored
staining and immunohistochemical stains (calcitonin, chromogranin A and CEA) were
processed by tissue microarray. CGH analysis was performed. Results : The Congo-red stain
was positive in only 12 cases. The immunohistochemical results were positive in 29 cases
for chromogranin A, 26 cases for CEA and 25 cases for calcitonin. DNA copy number changes
were found in 23 cases (79.3%). The most frequent change was a gain of 19q (65.5%); less
frequent changes were gain of 22 (55.2%), 19p (51.7%), 16p (27.58%), 17q (17.24%), and
loss of 4q (27.6%) and 3p (17.24%). Conclusions : DNA copy number changes of MTC were
more common (79.3%) than reported in previous studies. The most frequent changes were
gains in 19q, 22 and 19p.
참고문헌 (Reference)
1 Schmid KW, "‘‘Atypical’’ medullary thyroid carcinoma with little or no calcitonin expression" 433 : 209-215, 1998
2 Durham PL, "Serotonergic repression of Mitogen-activated protein kinase control of the calcitonin gene-related peptide enhancer" 12 : 1002-1009, 1998
3 Drosten M, "Role of MEN2Aderived RET in maintenance and proliferation of medullary thyroid carcinoma" 96 : 1231-1254, 2004
4 Thiagalingam A, "RREB-1, a novel zinc protein, is involved in the differentiation response to ras in human medullary thyroid carcinomas" 16 : 5335-5345, 1996
5 El-Rifai W, "Optimization of comparative genomic hybridization using flurochrome conjugated to dCTP and dUTP nucleotides" 77 : 699-700, 1997
6 Ray SK, "Novel transcriptional potentiation of beta2/neuroD on the secretin gene promoter by the DNA-binding protein Finb/RREB-1" 23 : 259-271, 2003
7 Abeln EC, "Molecular genetic analysis of flow-sorted ovarian tumour cells: Improved detection of loss of heterozygosity" 70 : 255-262, 1994
8 Leboulleux S, "Medullary thyroid carcinoma; Review" 61 : 299-310, 2004
9 Franc B, "Medullary thyroid carcinoma: search for histological predictors of survival (109 proband cases analysis)" 29 : 1078-1084, 1998
10 Gharib H, "Medullary thyroid carcinoma. Clinicopathologic features and long-term follow-up of 65 patients treated during 1946 through 1970" 67 : 934-940, 1992
1 Schmid KW, "‘‘Atypical’’ medullary thyroid carcinoma with little or no calcitonin expression" 433 : 209-215, 1998
2 Durham PL, "Serotonergic repression of Mitogen-activated protein kinase control of the calcitonin gene-related peptide enhancer" 12 : 1002-1009, 1998
3 Drosten M, "Role of MEN2Aderived RET in maintenance and proliferation of medullary thyroid carcinoma" 96 : 1231-1254, 2004
4 Thiagalingam A, "RREB-1, a novel zinc protein, is involved in the differentiation response to ras in human medullary thyroid carcinomas" 16 : 5335-5345, 1996
5 El-Rifai W, "Optimization of comparative genomic hybridization using flurochrome conjugated to dCTP and dUTP nucleotides" 77 : 699-700, 1997
6 Ray SK, "Novel transcriptional potentiation of beta2/neuroD on the secretin gene promoter by the DNA-binding protein Finb/RREB-1" 23 : 259-271, 2003
7 Abeln EC, "Molecular genetic analysis of flow-sorted ovarian tumour cells: Improved detection of loss of heterozygosity" 70 : 255-262, 1994
8 Leboulleux S, "Medullary thyroid carcinoma; Review" 61 : 299-310, 2004
9 Franc B, "Medullary thyroid carcinoma: search for histological predictors of survival (109 proband cases analysis)" 29 : 1078-1084, 1998
10 Gharib H, "Medullary thyroid carcinoma. Clinicopathologic features and long-term follow-up of 65 patients treated during 1946 through 1970" 67 : 934-940, 1992
11 Saad MF, "Medullary thyroid carcinoma. A study of the clinical features and prognostic factors in 161 patients" 63 : 319-342, 1984
12 Hazard JB, "Medullary (solid) carcinoma of the thyroid: a clinicopathologic entity" 19 : 152-161, 1959
13 Jee KJ, "Loss in 3p and 4p and Gain of 3q are concomitant aberrations in squamous cell carcinoma of the vulva" 14 : 377-381, 2001
14 Frisk T, "Expression of RET and its ligand complexes. GDNF/GFRalpha-1 and NTN/GFRalpha-2, in medullary thyroid carcinomas" 142 : 643-649, 2001
15 Hemmer S, "DNA copy number changes in thyroid carcinoma" 154 : 1539-1547, 1999
16 Frisk T, "CGH alterations in medullary thyroid carcinomas in relation to the RET M918T mutation and clinical outcome" 18 : 1219-1225, 2001
17 Liu Z, "Antiproliferative effects of Src inhibition on medullary thyroid cancer" 89 : 3503-3509, 2004
18 Greene FL, "American Joint Committee on Cancer Staging Manual, Sixth edition" Springer-Verlag New York, Inc, NY 10010 77-87, 2002
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분석정보
인용정보 인용지수 설명보기
학술지 이력
| 연월일 | 이력구분 | 이력상세 | 등재구분 |
|---|---|---|---|
| 2023 | 평가예정 | 해외DB학술지평가 신청대상 (해외등재 학술지 평가) | |
| 2020-01-01 | 평가 | 등재학술지 유지 (해외등재 학술지 평가) | |
| 2014-12-24 | 학술지명변경 | 한글명 : The Korean Journal of Pathology -> Journal of Pathology and Translational Medicine외국어명 : The Korean Journal of Pathology -> Journal of Pathology and Translational Medicine | |
| 2010-01-01 | 평가 | 등재학술지 유지 (등재유지) | |
| 2009-04-13 | 학술지명변경 | 한글명 : 대한병리학회지 -> The Korean Journal of Pathology | |
| 2007-01-01 | 평가 | 등재학술지 유지 (등재유지) | |
| 2005-01-01 | 평가 | 등재학술지 유지 (등재유지) | |
| 2002-01-01 | 평가 | 등재학술지 선정 (등재후보2차) | |
| 1999-07-01 | 평가 | 등재후보학술지 선정 (신규평가) |  |
학술지 인용정보
| 기준연도 | WOS-KCI 통합IF(2년) | KCIF(2년) | KCIF(3년) |
|---|---|---|---|
| 2016 | 0.13 | 0.13 | 0.12 |
| KCIF(4년) | KCIF(5년) | 중심성지수(3년) | 즉시성지수 |
| 0.13 | 0.11 | 0.409 | 0.01 |
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