Nematicidal Activity of Bikaverin and Fusaric Acid Isolated from Fusariumoxysporum against Pine Wood Nematode, Bursaphelenchus xylophilus

다국어 초록 (Multilingual Abstract)

Pine wood nematode, Bursaphelenchus xylophilus, causes
pine wilt disease in a number of Pinus species, which is
one of the most serious plant diseases in forest, Korea.
In the course of a search for nematicidal substances
from endophytic fungi, Fusarium oxysporum EF119 out
of the 23 fungal strains tested showed the strongest
activity to B. xylophilus. Two nematicidal substances
were isolated and identified as bikaverin and fusaric
acid. Fusaric acid showed somewhat higher nematicidal
activity against B. xylophilus than bikaverin; fusaric
acid and bikaverin, at 100 μg/ml, killed B. xylophilus
with mortality values of 50% and 43%, respectively. In
addition, both compounds acted synergistically. This is
the first report on the nematicidal activity of bikaverin
and fusaric acid.

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