험프리매트릭스 주파수배가시야검사법과 표준 자동시야검사법의 검사 지표에 대한 비교 분석 = Performance of Humphrey Matrix Frequency Doubling Technology Perimetry and Standard Automated Perimetry Global Indices

다국어 초록 (Multilingual Abstract)

Purpose: To evaluate and compare the diagnostic performance of Humphrey Matrix frequency doubling technology perimetry
(Matrix) global indices with standard automated perimetry (SAP) for glaucoma discrimination.
Methods: Forty-seven healthy and 63 glaucomatous subjects were included in this study. Glaucoma was defined as having
glaucomatous optic disc and glaucomatous visual field defect. Correlations of mean deviation (MD) and pattern standard deviation
(PSD) between Matrix and SAP were evaluated. Areas under receiver operating characteristic curves (AUCs) for discriminating
healthy from glaucoma, sensitivity, and cut-off value at fixed specificity of MD and PSD were determined in Matrix and SAP.
Results: MD and PSD from Matrix were highly correlated with SAP data in glaucomatous eyes (r =0.80, 0.69 p<0.001, <0.001).
The AUCs of MD and PSD from Matrix (0.941, 0.921) were of comparable diagnostic capability to SAP data (0.876, 0.923, p=0.068,
0.927). The sensitivity at 90% specificity of MD was 67.9% in SAP, 76.4% in Matrix, with the cut off value of MD at 90% specificity
at -3.10dB in SAP and -3.72dB in Matrix.
Conclusions: MD and PSD data from Matrix and SAP significantly correlated in glaucomatous eyes and showed similar diagnostic
performance for discriminating healthy from glaucoma however, both MD and PSD are scaled differently on SAP and Matrix,
which suggests that application of these parameters in a manner similar to that used in SAP should be employed with caution.

국문 초록 (Abstract)

목적: 매트릭스시야검사법과 표준 자동시야검사법의 global index를 비교하였다.
대상과 방법: 정상안 47, 녹내장안 63에 대해 mean deviation (MD)과 pattern standard deviation (PSD)의 상관관계, 녹내장과 정상안
을 감별하는 Areas under receiver operating characteristic curves (AUCs)값, 일정한 특이도에서 민감도 및 cut off값을 분석하였다.
결과: 녹내장안에서 두 시야검사의 MD와 PSD는 상관관계를 보였다(r=0.80, r=0.69). 매트릭스시야검사법의 MD, PSD의 AUC는(0.941,
0.921) 표준 자동 시야검사법과 (0.876, 0.923) 차이를 보이지 않았다(p=0.068, 0.927). 90%의 특이도에서 표준 자동시야검사와 매트
릭스시야검사의 MD의 민감도는 67.9%, 76.4%, cut off값은 -3.10dB과 -3.72dB였다.
결론: 두 시야 검사의 MD와 PSD는 상관관계를 보였고, 녹내장 진단력은 차이를 보이지 않았다. 그러나 유사한 특이도에서 cut off값은
차이를 보이므로 실제 임상에서 주의가 필요할 것이다.

참고문헌 (Reference)

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