Reserpine 投與로 일어나는 腦및 心筋 Catecholamine 含量의 變動에 미치는 Iproniazid와 Pyrogallol의 影響 = Influence of Iproniazid and Pyrogallol on the Catecholamine Liberation of Reserpine in Brain and Heart

다국어 초록 (Multilingual Abstract)

It is well known that catecholamines are usually metabolized by monoamine oxidase (MAO) and catechol-o-methyltransferase (COMT). It was postulated that iproniazid is MAO inhibitor and pyrogallol is a COMT inhibitor. Reserpine release the catecholamine from sympathetic innervated organ in small dose and deplete it in large dose. In this paper, the influence of iproniazid and pyrogallol on the reserpine induced catecholamine liberation in brain and myocardium of rabbits were studied.
The results were obtained as follows;
1. Catecholamine contents in brain and myocardium were increased by iproniazid injection and decreased by pyrogallol.
2. The decreased catecholamine contents induced by reserpine in brain and myocardium were significantly by iproniazid pretreatment and tended to increase by pyrogallol pretreatment. These findings were suggested that MAO is a major enzyme for the catecholamine metabolism in brain and myocardium.

목차 (Table of Contents)

• Ⅰ. 緖論
• Ⅱ. 實驗材料 및 方法
• Ⅲ. 實驗成績
• A. 大腦中 catecholamine 含量
• B. 心筋中 catecholamine 含量
• Ⅳ. 考察
• Ⅴ. 結論
• 參考文獻