Protective role of caffeic acid in an Aβ25-35-induced Alzheimer’s disease model

다국어 초록 (Multilingual Abstract)

BACKGROUND/OBJECTIVES: Alzheimer’s disease (AD) is characterized by deficits in memory and cognitive functions. The accumulation of amyloid beta peptide (Aβ) and oxidative stress in the brain are the most common causes of AD.
MATERIALS/METHODS: Caffeic acid (CA) is an active phenolic compound that has a variety of pharmacological actions. We studied the protective abilities of CA in an Aβ25-35-injected AD mouse model. CA was administered at an oral dose of 10 or 50 ㎎/㎏/day for 2 weeks. Behavioral tests including T-maze, object recognition, and Morris water maze were carried out to assess cognitive abilities. In addition, lipid peroxidation and nitric oxide (NO) production in the brain were measured to investigate the protective effect of CA in oxidative stress.
RESULTS: In the T-maze and object recognition tests, novel route awareness and novel object recognition were improved by oral administration of CA compared with the Aβ25-35-injected control group. These results indicate that administration of CA improved spatial cognitive and memory functions. The Morris water maze test showed that memory function was enhanced by administration of CA. In addition, CA inhibited lipid peroxidation and NO formation in the liver, kidney, and brain compared with the Aβ25-35-injected control group. In particular, CA 50 ㎎/㎏/day showed the stronger protective effect from cognitive impairment than CA 10 ㎎/㎏/day.
CONCLUSIONS: The present results suggest that CA improves Aβ25-35-induced memory deficits and cognitive impairment through inhibition of lipid peroxidation and NO production.

목차 (Table of Contents)

• INTRODUCTION5
• MATERIALS AND METHODS
• RESULTS
• DISCUSSION
• REFERENCES

참고문헌 (Reference)

1 Eom TK, "β-secretase inhibitory activity of phenolic acid conjugated chitooligosaccharides" 28 : 214-217, 2013

2 Lu P, "Xanthoceraside attenuates amyloid β peptide(25-35)-induced learning and memory impairments in mice" 219 : 181-190, 2012

3 Behl C, "Vitamin E protects nerve cells from amyloid beta protein toxicity" 186 : 944-950, 1992

4 National Institute of Food and Drug Safety Evaluation (KR), "Tox-Info. Caffeic acid" National Institute of Food and Drug Safety Evaluation

5 Lalonde R, "The neurobiological basis of spontaneous alternation" 26 : 91-104, 2002

6 Choi JY, "Tartary buckwheat improves cognition and memory function in an in vivo amyloid-β-induced Alzheimer model" 53 : 105-111, 2013

7 Tsunekawa H, "Synergistic effects of selegiline and donepezil on cognitive impairment induced by amyloid beta (25-35)" 190 : 224-232, 2008

8 Schmidt HH, "Regulation and subcellular location of nitrogen oxide synthases in RAW264.7 macrophages" 41 : 615-624, 1992

9 Rottkamp CA, "Redox-active iron mediates amyloid-beta toxicity" 30 : 447-450, 2001

10 Huang Y, "Protective effects of caffeic acid and caffeic acid phenethyl ester against acrolein-induced neurotoxicity in HT22 mouse hippocampal cells" 535 : 146-151, 2013

11 Sul D, "Protective effect of caffeic acid against beta-amyloid-induced neurotoxicity by the inhibition of calcium influx and tau phosphorylation" 84 : 257-262, 2009

12 Yan JJ, "Protection against β-amyloid peptide toxicity in vivo with long-term administration of ferulic acid" 133 : 89-96, 2001

13 Ono K, "Potent anti-amyloidogenic and fibril-destabilizing effects of polyphenols in vitro: implications for the prevention and therapeutics of Alzheimer's disease" 87 : 172-181, 2003

14 Manach C, "Polyphenols:food sources and bioavailability" 79 : 727-747, 2004

15 Salah N, "Polyphenolic flavanols as scavengers of aqueous phase radicals and as chain-breaking antioxidants" 322 : 339-346, 1995

16 Markesbery WR, "Oxidative alterations in Alzheimer's disease" 9 : 133-146, 1999

17 Choi YY, "Oligonol improves memory and cognition under an amyloid β(25-35)-induced Alzheimer's mouse model" 34 : 595-603, 2014

18 Bevins RA, "Object recognition in rats and mice: a one-trial non-matching-to-sample learning task to study 'recognition memory'" 1 : 1306-1311, 2006

19 Butterfield D, "Nutritional approaches to combat oxidative stress in Alzheimer's disease" 13 : 444-461, 2002

20 Chung TW, "Novel and therapeutic effect of caffeic acid and caffeic acid phenyl ester on hepatocarcinoma cells: complete regression of hepatoma growth and metastasis by dual mechanism" 18 : 1670-1681, 2004

21 Doraiswamy PM, "Non-cholinergic strategies for treating and preventing Alzheimer's disease" 16 : 811-824, 2002

22 Barnham KJ, "Neurodegenerative diseases and oxidative stress" 3 : 205-214, 2004

23 Kim J, "Naturally occurring phytochemicals for the prevention of Alzheimer's disease" 112 : 1415-1430, 2010

24 Scapagnini G, "Modulation of Nrf2/ARE pathway by food polyphenols: a nutritional neuroprotective strategy for cognitive and neurodegenerative disorders" 44 : 192-201, 2011

25 Cotman CW, "Mechanisms of neuronal death in Alzheimer's disease" 6 : 493-506, 1996

26 Wypijewska A, "Iron and reactive oxygen species activity in parkinsonian substantia nigra" 16 : 329-333, 2010

27 Nunomura A, "Involvement of oxidative stress in Alzheimer disease" 65 : 631-641, 2006

28 Laursen SE, "Intracerebroventricular injections in mice. Some methodological refinements" 16 : 355-357, 1986

29 Bachman DL, "Incidence of dementia and probable Alzheimer's disease in a general population: the Framingham Study" 43 : 515-519, 1993

30 Kubo T, "In vivo conversion of racemized beta-amyloid ([D-Ser 26]A beta 1-40) to truncated and toxic fragments ([D-Ser 26]A beta 25-35/40) and fragment presence in the brains of Alzheimer's patients" 70 : 474-483, 2002

31 Soliman KF, "In vitro attenuation of nitric oxide production in C6 astrocyte cell culture by various dietary compounds" 218 : 390-397, 1998

32 Khan KA, "Impact of caffeic acid on aluminium chloride-induced dementia in rats" 65 : 1745-1752, 2013

33 Takahata K, "Effects of selegiline alone or with donepezil on memory impairment in rats" 518 : 140-144, 2005

34 Shinomiya K, "Effects of chlorogenic acid and its metabolites on the sleep-wakefulness cycle in rats" 504 : 185-189, 2004

35 Muthaiyah B, "Dietary supplementation of walnuts improves memory deficits and learning skills in transgenic mouse model of Alzheimer's disease" 42 : 1397-1405, 2014

36 Scalbert A, "Dietary polyphenols and the prevention of diseases" 45 : 287-306, 2005

37 Morris R, "Developments of a water-maze procedure for studying spatial learning in the rat" 11 : 47-60, 1984

38 Lee AY, "Cognition and memory function of Taraxacum coreanum in an in vivo amyloid-β-induced mouse model of Alzheimer's disease" 66 : 1357-1366, 2014

39 Moridani MY, "Caffeic acid, chlorogenic acid, and dihydrocaffeic acid metabolism: glutathione conjugate formation" 29 : 1432-1439, 2001

40 Touaibia M, "Caffeic acid, a versatile pharmacophore: an overview" 11 : 695-713, 2011

41 Roos TU, "Caffeic acid phenethyl ester inhibits PDGF-induced proliferation of vascular smooth muscle cells via activation of p38 MAPK, HIF-1α, and heme oxygenase-1" 74 : 352-356, 2011

42 Butterfield DA, "Beta-amyloid-associated free radical oxidative stress and neurotoxicity: implications for Alzheimer's disease" 10 : 495-506, 1997

43 Selkoe DJ, "Beta-amyloid precursor protein of Alzheimer disease occurs as 110- to 135-kilodalton membrane-associated proteins in neural and nonneural tissues" 85 : 7341-7345, 1988

44 Sandbrink R, "Beta A4-amyloid protein precursor mRNA isoforms without exon 15 are ubiquitously expressed in rat tissues including brain, but not in neurons" 269 : 1510-1517, 1994

45 U Rehman M, "Attenuation of oxidative stress, inflammation and early markers of tumor promotion by caffeic acid in Fe-NTA exposed kidneys of Wistar rats" 357 : 115-124, 2011

46 Ohkawa H, "Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction" 95 : 351-358, 1979

47 Ono K, "Anti-amyloidogenic activity of tannic acid and its activity to destabilize Alzheimer's betaamyloid fibrils in vitro" 1690 : 193-202, 2004

48 Avdulov NA, "Amyloid beta-peptides increase annular and bulk fluidity and induce lipid peroxidation in brain synaptic plasma membranes" 68 : 2086-2091, 1997

49 Butterfield DA, "Amyloid beta-peptide(1-42)contributes to the oxidative stress and neurodegeneration found in Alzheimer disease brain" 14 : 426-432, 2004

50 Butterfield DA, "Amyloid beta-peptide (1-42)-induced oxidative stress and neurotoxicity: implications for neurodegeneration in Alzheimer's disease brain. A review" 36 : 1307-1313, 2002

51 Roher AE, "Amyloid beta peptides in human plasma and tissues and their significance for Alzheimer's disease" 5 : 18-29, 2009

52 Maurice T, "Amnesia induced in mice by centrally administered β-amyloid peptides involves cholinergic dysfunction" 706 : 181-193, 1996

53 Choi SJ, "Ameliorative effect of 1,2-benzenedicarboxylic acid dinonyl ester against amyloid beta peptide-induced neurotoxicity" 16 : 15-24, 2009

54 Selkoe DJ, "Alzheimer's disease: a central role for amyloid" 53 : 438-447, 1994

55 Mattson MP, "Abeta25-35 induces rapid lysis of red blood cells: contrast with Aβ1-42 and examination of underlying mechanisms" 771 : 147-153, 1997

56 Montgomery KC, "A test of two explanations of spontaneous alternation" 45 : 287-293, 1952