Nadroparin calcium을 5% 포도당 수액에 희석시의 안정성 연구 = The stability of nadroparin calcium in 5% dextrose solution

다국어 초록 (Multilingual Abstract)

Nadroparin is a low-molecular-weight heparin and has been effective in the prophylaxis and treatment of thromboembolism. Nadroparin is usually used for prevention of hepatic venoocclusive disease in SNUCH. Hepatic veno-occlusive disease (VOD, a common complication of stem cell transplantation) is a result of intensive conditioning by chemo-radio-therapy. The pathogenesis is probably multifactorial, but the key event is endothelial damage, which triggers the coagulation cascade, inducing the deposition of fibrin in the affected venules. Thus, the use of antithrombotic therapy is a logical prophylactic approach to VOD. Since immune function and platelet number is decreased after stem cell transplantation, nadroparin in 5% dextrose solution is continuously infused for 24 hours instead of subcutaneous injection but it is failed to cite data on the stability of nadroparin with diluent. The stability of nadroparin in 5% dextrose solution was studied. Duplicate solutions of 5,700 IU/0.6 ml of nadroparin and 100 ml of 5% dextrose solution were prepared. Samples were taken at 15 minutes, 2 hours, and 24 hours. Inspections for color change and precipitation performed with naked eyes. Samples were evaluated for pharmacologic activity by anti-factor Xa assay according to European Pharmacopoeia 4th. Throughout the 24-hour study period, the nadroparin admixtures were free of color change, precipitates. The pharmacologic activity of nadroparin remained 99.8~100.5% of activity measured immediately preparation. In conclusion, nadroparin 57 IU/ml in 5% dextrose solution based on 50 kg child was stable for up to 24 hours at 15~25°C.