자일로올리고당을 함유한 설탕이 20대 여성의 변비 개선에 미치는 효과: 이중맹검 연구 = Effect of xylooligosaccharide-sugar mixture on defecation frequency and symptoms in young women with constipation: a randomized, double-blind, placebo-controlled trial

다국어 초록 (Multilingual Abstract)

Purpose: To investigate the effects of the intake of xylooligosaccharide-sugar mixture (XOS) on defecation frequency andsymptoms in 56 young women (mean age of 22.1 years old) with constipation. Methods: Two experiments were conducted.
In experiment 1, a randomized double-blind study was performed to evaluate the effect of 6 weeks' intake of 10 g sucrosecontaining 7% xylooligosaccharide or 10 g sucrose on constipation. In experiment 2, 24 g coffee mixture containing 12.8 gplant cream and 11.2 g xylooligosaccharide-sugar mixture was consumed by the subjects. During the study, the clinicalefficacy was assessed by using a daily diary. The subjects indicated the number of frequencies they defecated in a dayand the clinical symptom scores. Results: In experiment 1, the mean frequency of defecations was 2.07 in the pretreatmentweek and increased significantly to 4.05, 4.42, 4.84, 4.84, and 4.05 in weeks 2 to 6 of XOS intake, in comparison with the3-3.67 with sucrose intake (sucrose, SUC). In experiment 2, the mean frequency of defecations significantly increased from2.47 in the pretreatment week to 4.11-5.67 in weeks 1-6 of XOS intake. The occurrence of very loose or loose stools in theXOS group was significantly increased in weeks 5 and 6, compared with the pretreatment week and SUC group. XOS intakesignificantly alleviated the abdominal displeasure and feeling of residual stool leftness in weeks 2, 3, 5, and 6, while SUCdid so in weeks 4 and 6 (p < 0.05). The coffee mixture containing xylooligosaccharide-sugar mixture reduced theabdominal displeasure and feeling of residual stool leftness from week 3 until the end of the experiment (p < 0.05).
Conclusion: Our results suggest that xylooligosaccharide-sugar mixture intake was effective, without adverse effects, forthe alleviation of constipation in the young women in this study.

국문 초록 (Abstract)

본 연구는 자일로올리고당을 설탕에 혼합하여 변비를앓고 있는 젊은 여성을 대상으로 변비개선효과를 확인하였다. 평균연령 22.1세인 젊은 여성 56명을 대상으로 실험1에서는 설탕을 플라시보로 하는 이중맹검 임상연구를 통해 자일로올리고당 0.7 g이 함유된 설탕 10 g (n = 19명) 또는 설탕 10 g (n = 19명)을 블랙커피와 함께 복용하도록 하였고, 실험 2에서는 자일로올리고당 0.4 g 함유한 설탕 5.6 g과 1.6 g의 커피, 4.8 g의 식물성 크림이 함유된 커피믹스를 1일 2회씩 6주간 섭취하도록 하였다 (n = 18명). 섭취결과 XOS군과 XOSmix군의 경우 섭취전 주간 배변횟수가2.47회에서 섭취 1주째부터 증가하여 섭취 6주째에는 주간배변횟수가 4.11회와 5.67회로 각각 증가하였다. XOS와XOS 함유 커피믹스는 통계적으로 유의하게 복부 불쾌감과 잔변감을 개선하였으며, 배변횟수의 증가는 섭취초반부터 효과가 있는 것으로 나타났다. 따라서 XOS는 0.7 g의적은양으로도 변비를 개선하는 효과가 있는 것으로 나타나 음료에 기능성을 갖춘 감미료로서의 활용이 기대된다.

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