느릅나무 추출물의 항균효과와 상처치유효과 = The Antimicrobial activity and wound healing Effect of Ulmi cortex Extracts

다국어 초록 (Multilingual Abstract)

To evaluate the antimicrobial activity and the effects of wound healing of Ulmi cortex in the use of full thickness wound model in rat. Experiment 1: The solvent extracts of Ulmi cortex, which were extracted by using methanol and water, were prepared. The antimicrobial activities were investigated to each strain with the different contents. Methanol extracts showed the antimicrobial activity in the contents of Ulmi cortex 100 ㎍ and 1000 ㎍.
Experiment 2: Six male Sprague-Dawley rats were used in the study. The rats were anesthetized with ketamine 90mg/kg. Circular, full-thickness wounds were made for each animal with 6mm dermatologic punch biopsy. Ulmi cortex extracts was applied topically three times a day in the study group(n=3), saline in the control group(n=3). On 4 day and 7 day, the wounds were photographed and excised. There was no clear histopathologic difference at day 4 in terms of cellular reaction and vascular proliferation. The reepithelialization ana the growth of granulation tissues were prominent in the study group at day 6. In this study, the Ulmi cortex extracts had antimicrobial activity and some benefit on wound heating.