Polar Body: Indicator of Oocyte's Maturation, Have Any Function on Oocyte?

다국어 초록 (Multilingual Abstract)

Polar body was usually used as a determinant of oocyte's maturation. Polar body morphology could reflect the embryo quality and implantation competence. This review only focuses on morphology of the first polar body and embryo developmental rate in the presence or absence of polar body. However, it is very difficult to describe whether polar body has any effects on embryo development in vitro or in vivo. Further intensive research is needed to determine its function on embryo development.

참고문헌 (Reference)

1 Dyban AP, "Visualization of second polar body chromosomes in fertilized and artificial activated mouse oocytes treated with okadaic acid" 95 : 572-579, 1992

2 Gilbert S, "The saga of the germ line. Developmental Biology" Sinauer 788-825, 1991

3 Wakayama T, "The first polar body can be used for the production of normal offspring in mice" 59 : 100-104, 1998

4 Choi T, "The Mos/mitogen-activated protein kinase (MAPK) pathway regulates the size and degeneration of the first polar body in maturing mouse oocytes" 93 : 7032-7035, 1996

5 Ebner T, "Prognostic value of first polar body morphology on fertilization rate and embryo quality in intracytoplasmic sperm injection" 15 : 427-430, 2000

6 Wheeler MB, "Production of live offspring with predicted genotypes using PCR-RFLP analysis of polar bodies from mouse oocytes" 40 : 267-272, 1995

7 Ortiz ME, "Postovulatory aging of human ova: II. Spontaneous division of the first polar body" 7 : 269-276, 1983

8 De Santis L, "Polar body morphology and spindle imaging as predictors of oocyte quality" 11 : 36-42, 2005

9 Verlinsky Y, "Polar body diagnosis of common aneuploidies by FISH" 13 : 157-162, 1996a

10 Wakayama T, "Participation of the female pronucleus derived from the second polar body in full embryonic development of mice" 110 : 263-266, 1997

11 Wakayama T, "Full-term development of mice from enucleated oocytes injected with cumulus cell nuclei" 394 : 369-374, 1998

12 Ciotti PM, "First polar body morphology before ICSI is not related to embryo quality or pregnancy rate" 19 : 2334-2339, 2004

13 Ebner T, "Elective transfer of embryos selected on the basis of first polar body morphology is associated with increased rates of implantation and pregnancy" 72 : 599-603, 1999

14 Fancsovits P, "Correlation between first polar body morphology and further embryo development" 57 : 331-338, 2006

15 Verlinsky Y, "Birth of healthy children after preimplantation diagnosis of common aneuploidies by polar body fluorescent in situ hybridization analysis. Preimplantation Genetics Group" 66 : 126-129, 1996b

16 Takase K, "Apoptosis in the degenerated process of unfertilized mouse ova" 175 : 69-76, 1995

17 Verlinsky Y, "Analysis of the first polar body: preconception genetic diagnosis" 5 : 826-829, 1990

18 Evsikov AV, "A study of the first and second polar bodies in mouse oogénesis" 26 : 196-200, 1995