유산소성 운동이 중,고령자의 혈장 산화질소 대사산물에 미치는 영향 = Effects of Aerobic Exercise on Plasma Nitric Oxide Metabolites in Middle-aged to Older Adults

국문 초록 (Abstract)

이 연구의 목적은 중 ㆍ고령자에 있어서 산화질소(Nitric Oxide, NO) 생성에 관련된 혼란변수(confounding factor)가 유산소성 운동에 의한 NO 변화에 어떠한 영향을 미치는가를 분석하는데 있다. 건강한 50-70세 52명(남: n=27, 여: n=25)에게 6개월간 3 d/wk, 70% VO_2max, 40 min/d 유산소성 운동을 실시하였다. NO는 Griess법을 이용하여 혈장 NO 대산산물(NO metabolites, NOx)를 분석하였다. 안정시 혈장 NOx와 총콜레스테롤(TC) 및 저밀도지단백 콜레스테롤(LDL-C)은 유의한 역상관계(각각 r= -0.313, p=.016와 r=-0.307, p=.019)를 나타냈다. 그러나 공복 혈당, 인슐린, 중성지방 (TG), 및 고밀도지단백 콜레스테롤 (HDL-C)은 혈장 NOx와 관련이 없었다. 유산소성 운동 후 최대산소섭취량(VO_2max)와 HDL-C는 유의하게(p<.05) 증가하였지만 체중, 체질량지수(BMI), 체지방률(%fat), TG, 및 공복 인슐린은 유의하게(p<.05) 감소하였다. 혈장 NOx는 운동 전 20.1±0.7 μ㏖/L에서 운동 후 19.4±0.7 μ㏖/L로 유의한 변화가 없었으나 TC과 LDL-C를 공변량으로 한 공분산 분석 후 이러한 변화는 유의한(p=.002) 것으로 나타났다. 이러한 결과는 유산소성 운동이 NO 생성에 영향을 미치지 않을 수 있으며, NO 변화에 대한 TC와 LDL-C의 영향을 보정한다면 오히려 NO 생성을 감소시킬 수 있다는 것을 시사한다.

다국어 초록 (Multilingual Abstract)

The purpose of the study was to investigate whether exercise training affected basal nitric oxide (NO) production and whether other confounding factors were associated with changes in basal NO production. Fifty two healthy sedentary subjects (aged 50-70 yrs, men=27, women=25) completed 6 months of exercise training at 70% of VO_2max, 40 min/d, 3 d/wk. NO production was determined as the measure of plasma NO metabolites (NOx) using a modified Griess assay. At baseline, there were significant inverse correlations between basal plasma NOx levels and total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) levels (r=-0.313, p=.016 and r= -0.307, p=.019, respectively). Fasting plasma glucose, insulin, triglyceride (TG), and high-density lipoprotein cholesterol (HDL-C) levels were not correlated with basal plasma NOx levels at baseline. After exercise training, VO_2max and HDL-C were significantly increased, and body weight, body mass index (BMI), percent body fat, TG, and fasting plasma insulin levels were significantly reduced (p<.05). Plasma NOx levels were not changed with exercise training, but significantly reduced from 20.1±0.7 μmol/L to 19.4±0.7 μmol/L (p=.002) after statistical adjustment for baseline TC and LDL-C. The present results indicate that exercise training may not change NO production, but when TC and LDL-C levels are accounted for, exercise training may decrease NO production.

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