Mori Cortex Radicis extract inhibits human norovirus surrogate in simulated digestive conditions

다국어 초록 (Multilingual Abstract)

Norovirus is a major cause of acute gastroenteritisglobally, resulting in enormous health and societalcosts. In this study, the antiviral activities of Mori CortexRadicis (MCR) extract and its bioactive flavonoids, morusinand kuwanon G, were tested against murine norovirus(MNV), a human norovirus surrogate, using plaque assay.
The antiviral activity was confirmed in simulated digestiveconditions, including simulated saliva fluid (SSF), simulatedgastric fluid (SGF), and simulated intestinal fluid(SIF). Pre-treatment of MNV with MCR extract at1000 lg/mL showed antiviral activity with a 1.1-logreduction. Morusin and kuwanon G also demonstrated a1.0-log and 0.6-log reductions of MNV titers, respectively,at 100 lM. MCR extract at a concentration of 2 mg/mL inSSF, SGF, and SIF markedly reduced MNV titers by 1.8,1.9, and 1.5 logs, respectively. Therefore, these data suggestthat MCR extract can be used to control norovirusinfectivity.

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