수명이 짧은 예쁜꼬마선충은 수명 연장 등 많은 연구의 모델생물으로서 사용되고있다. 해조류 추출물들이 포함된 선충배양용 한천배지에서 선충(N2 야생형)을 키우면서 그 수명을 측정하였...
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https://www.riss.kr/link?id=A106413354
2019
English
KCI등재
학술저널
1120-1125(6쪽)
0
0
상세조회0
다운로드국문 초록 (Abstract)
수명이 짧은 예쁜꼬마선충은 수명 연장 등 많은 연구의 모델생물으로서 사용되고있다. 해조류 추출물들이 포함된 선충배양용 한천배지에서 선충(N2 야생형)을 키우면서 그 수명을 측정하였...
수명이 짧은 예쁜꼬마선충은 수명 연장 등 많은 연구의 모델생물으로서 사용되고있다. 해조류 추출물들이 포함된 선충배양용 한천배지에서 선충(N2 야생형)을 키우면서 그 수명을 측정하였다. 13종의 흔한 해조류 중에서 갈조류 톳의 에탄올추출물이 난 부화, 성장 및 생존율에서 가장 큰 효과를 보였다. 그 수명은 에탄올추출물(0.05mg/ml) 및 주 활성성분인 fucosterol (0.05 mg/ml) 첨가에 의하여 1.54배 및 1.23배 정도로 유의미하게 증가되었다. 또한 에탄올추출물에 의하여 chemotaxis는 1.13배 증가, 한 배에서의 새끼는 0.74배 감소, 첫 산란시기는 0.96배 단축되었다. 이와 같은 결과들로 보아서 양식 가능한 해조류 톳은 건강에 이로운 건강보조 식품으로서의 좋은 재료가 될 수 있을 것이다.
다국어 초록 (Multilingual Abstract)
The short-lived nematode Caenorhabditis elegans has been used as a model organism for many studies, including lifespan extension. To screen common seaweeds for natural anti-aging agents, the lifespan of C. elegans (N2 wild-type strain) was measured by...
The short-lived nematode Caenorhabditis elegans has been used as a model organism for many studies, including lifespan extension. To screen common seaweeds for natural anti-aging agents, the lifespan of C. elegans (N2 wild-type strain) was measured by its hatch rate, growth rate, survival rate, chemotaxis, brood size, and egg-laying time after exposure to nematode growth medium (NGM) containing seaweed extracts. Approximately 30 animals synchronized at the first larval stage were incubated until they reached their adult stages before laying their eggs and were transferred to fresh NGM every 3 days. We also identified the major active compound from the seaweed by gas chromatography-mass spectrometry and tested its optimal dose for longevity. Of 13 common seaweed species, an ethanol extract of the brown seaweed Hizikia fusiformis showed the greatest effect on hatching, growth, and survival rates. The lifespan of C. elegans was significantly expanded 1.54-fold and 1.23-fold in the presence of the ethanol extract (0.05 mg/ml) and the main active component, fucosterol (0.05 mg/ml), respectively. Exposure to the ethanol extract also increased chemotaxis 1.13-fold, decreased brood size 0.74-fold, and shortened egg-laying time 0.96-fold. These results suggest that the aquaculturable H. fusiformis may be a promising source of a diet supplement to support health care.
목차 (Table of Contents)
참고문헌 (Reference)
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2 Karawita, R., "Reactive oxygen species scavenging, metal chelating, reducing power and lipid oxydation inhibition properties of different solvent fractions from Hizikia fusiformis" 220 : 363-371, 2005
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4 Dai, M. C., "Phospholipid studies of marine organisms: 26, Interactions of some marine sterols with 1-stearoyl02-oleoylphosphatidylcholine (SOPC) in model membranes" 59 : 245-253, 1991
5 Pangestuti, R., "Neuroprotective effects of marine algae" 9 : 803-818, 2011
6 Maglioni, S., "Mitochondrial stress extends lifespan in C. elegans through neuronal hormesis" 56 : 89-98, 2014
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8 Sundararajan, L., "Mechanisms that regulate morphogenesis of a highly branched neuron in C. elegans" 451 : 53-67, 2019
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10 Korea Fisheries Association, "Korean Fisheries Yearbook" Uno Design Press 541-, 2017
1 Donguibogam Committee, "Translated Donguibogam" Bubinmunwha Press 2198-, 1999
2 Karawita, R., "Reactive oxygen species scavenging, metal chelating, reducing power and lipid oxydation inhibition properties of different solvent fractions from Hizikia fusiformis" 220 : 363-371, 2005
3 Kim, S. K., "Potential beneficial effects of marine algal sterols on human health" 64 : 191-198, 2011
4 Dai, M. C., "Phospholipid studies of marine organisms: 26, Interactions of some marine sterols with 1-stearoyl02-oleoylphosphatidylcholine (SOPC) in model membranes" 59 : 245-253, 1991
5 Pangestuti, R., "Neuroprotective effects of marine algae" 9 : 803-818, 2011
6 Maglioni, S., "Mitochondrial stress extends lifespan in C. elegans through neuronal hormesis" 56 : 89-98, 2014
7 Smit, A. J, "Medicinal and pharmaceutical uses of seaweed natural products : a review" 16 : 245-262, 2004
8 Sundararajan, L., "Mechanisms that regulate morphogenesis of a highly branched neuron in C. elegans" 451 : 53-67, 2019
9 Yagi, K, "Lipid peroxides and human diseases" 45 : 337-351, 1987
10 Korea Fisheries Association, "Korean Fisheries Yearbook" Uno Design Press 541-, 2017
11 Lee, Y., "Inverse correlation between longevity and developmental rate among wild C. elegans strains" 8 : 986-999, 2016
12 Abdul, Q. A., "Health benefit of fucosterol from marine algae : a review" 96 : 1856-1866, 2016
13 The C. elegans sequencing consortium, "Genome sequence of the nematode C. elegans: a platform for investigating biology" 282 : 2012-2018, 1998
14 Kim, B., "Gene function prediction based on developmental transcriptomes of the two sexes in C. elegans" 17 : 917-928, 2016
15 Maeda, H., "Fucoxanthin from edible seaweed, Undaria pinnatifida, shows antiobesity effect through UCP1 expression in white adipose tissues" 332 : 392-397, 2005
16 Gyu-Won Huh, "Fucosterols from Hizikia fusiformis and Their Proliferation Activities on Osteosarcoma-derived Cell MG63" 한국응용생명화학회 55 (55): 551-555, 2012
17 Tseng, C. K., "Chinese seaweeds in herbal medicine" 116/117 : 152-154, 1984
18 Strange, K., "C. elegans Methods and Applications" Humana Press 287-, 2006
19 Pant, A., "Bioactive phytomolecules and ageing in Caenorhabditis elegans" 4 : e19-, 2015
20 Frøkjær-Jensen, C., "Ammonium-acetate is sensed by gustatory and olfactory neurons in Caenorhabditis elegans" 3 : e2467-, 2008
21 Dawczynski, C., "Amino acids, fatty acids, and dietary fibre in edible seaweed products" 103 : 891-899, 2007
22 Gems, D., "Alternative perspectives on aging in Caenorhabditis elegans : reactive oxygen species or hyperfunction?" 19 : 321-329, 2013
23 Ma, Z., "Allelopathic interactions between the macroalga Hizikia fusiformis(Harvey)and the harmful blooms-forming dinoflagellate Karenia mikimotoi" 65 : 19-26, 2017
24 Guiry, M. D., "AlgaeBase: World-wide electronic publication" National University of Ireland
Sarracenia purpurea에서 빛 및 질소 의존성 anthocyanin 생합성
자외선 B에 유도된 사람유래 HaCaT cells에서의 오미자 종자 분획물의 항산화 및 항노화 효과
연 및 neferine의 암세포 항 성장 및 세포사멸 활성
학술지 이력
연월일 | 이력구분 | 이력상세 | 등재구분 |
---|---|---|---|
2027 | 평가예정 | 재인증평가 신청대상 (재인증) | |
2021-01-01 | 평가 | 등재학술지 유지 (재인증) | |
2018-01-01 | 평가 | 등재학술지 유지 (등재유지) | |
2015-01-01 | 평가 | 등재학술지 유지 (등재유지) | |
2011-08-03 | 학술지명변경 | 외국어명 : Korean Journal of Life Science -> Journal of Life Science | |
2011-01-01 | 평가 | 등재학술지 유지 (등재유지) | |
2009-01-01 | 평가 | 등재학술지 유지 (등재유지) | |
2007-01-01 | 평가 | 등재학술지 유지 (등재유지) | |
2004-01-01 | 평가 | 등재학술지 선정 (등재후보2차) | |
2003-01-01 | 평가 | 등재후보 1차 PASS (등재후보1차) | |
2001-07-01 | 평가 | 등재후보학술지 선정 (신규평가) |
학술지 인용정보
기준연도 | WOS-KCI 통합IF(2년) | KCIF(2년) | KCIF(3년) |
---|---|---|---|
2016 | 0.37 | 0.37 | 0.42 |
KCIF(4년) | KCIF(5년) | 중심성지수(3년) | 즉시성지수 |
0.43 | 0.43 | 0.774 | 0.09 |