In vitro and In Vivo photothermal cancer therapy with pH tunable Bio-imaging by using IR825 integrated fluorescence nanoparticles = In vitro and In Vivo photothermal cancer therapy with pH tunable Bio-imaging by using IR825 integrated fluorescence nanoparticles

다국어 초록 (Multilingual Abstract)

We report a combined diagnostic fluorescence for bioimaging and therapeutic fluorescence for photothermal therapy (PTT) within an integrate hybrid nanoparticles can simultaneously and accurately diagnosis and ablates the tumor. This new class triggered photothermal therapeutic agents for pH responsive cancer cells target bio-imaging constructed using near-infrared dye (NIR) IR825, polymer conjugated anchored reduced graphene oxide (rGO) hybrid nanoparticles. Using hybrid nanoparticles administered PTT agents, the time-dependent in vivo tumor accumulated hybrid nanoparticles generated require photothermal heat, which caused dominant suppression of tumor growth. The ability to maximize tumor therapy and to monitor treatment condition in target area explores an appealing interest for the successful application of photothermal therapy. This was supported by Korea National University of Transportation in 2015.