Effects of resistance‐induced heat on mice skin

다국어 초록 (Multilingual Abstract)

The continuous exposure to solar radiation happens to most living beings, their interaction with humans can be both positive or negative. Much of the research into its effects refers to ultraviolet (UV) and its consequences, such as skin damage and aging, with little emphasis on the effects of heat alone. The aim of this work was to investigate macroscopic, microscopic and biochemical effects of heat‐induced thermal exposure on mouse skin. Mice were divided into control (23° C – room temperature) and exposed (43° C) groups, with heat exposure induced by resistance plate in a thermal chamber for 30 minutes for 14 days on alternate days and at the end skin samples were collected for analysis. A thickness analysis of the skin layers was performed, where we observed an increase in the thickness of the dermis as well as the epidermis in the groups exposed to heat. In addition, there was an increase in the elastic and collagen fibers deposition in the 43° C group when compared to the control group. We performed a protein quantification for type I collagen, and observed a decrease in pre collagen in the 43° C group, while the mature collagen showed a slight increase in the same group, suggesting a possible renewal of this collagen, stimulated by heat. We also investigated the levels of oxidative stress in these conditions, and observed that reduction in lipid peroxidation, nitrite levels and free radicals in groups exposed to high temperature. With all these findings our results suggest that heat, without radiation, can behave as an important factor of skin anti‐aging.
Support or Funding Information
Supported by: FAPERJ and CNPq
This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.