고도 이형성증을 동반한 산발성 위저선 용종 1예 = A Case of High Grade Dysplasia in Sporadic Fundic Gland Polyp

다국어 초록 (Multilingual Abstract)

Fundic gland polyps (FGP) are the most common type of gastric polyps, with an incidence on endoscopy of 0.8∼1.9%. They have been considered as benign lesions, without the potential for malignant transformation. High grade dysplasia and gastric adenocarcinomas associated with FGP have been described in patients with familial, as well as attenuated adenomatous polyposis (FAP). In contrast, dysplasia associated with FGP in non-FAP patients is extremely rare, and there have been no reports of sporadic FGP with high grade dysplasia in the Korean literature. Herein, we report one case of high grade dysplasia associated with sporadic FGP in a non-FAP patient treated with an endoscopic polypectomy. (Korean J Gastrointest Endosc 2006;32:338-341)

국문 초록 (Abstract)

위저선 용종은 위저선의 증식과 소낭으로 구성된 용종으로 내시경 검사에서 0.8～1.9%의 빈도로 나타나는 위용종이다. 이들은 대체로 양성이며 악성 변화는 거의 없다. 간혹 가족성 선종성 용종증 및 약화 가족성 선종성 용종증을 동반한 위저선 용종에서 고도 이형성증 및 선암이 발생할 수 있으나 산발성 위저선 용종의 악성 변화는 특히 드물며 이제까지 국내 보고는 없었다. 본 저자는 가족성 선종성 용종증 없이 발생한 산발성 위저선 용종에 고도 이형성증을 동반한 환자에서 내시경 용종절제술을 시행하여 완치한 1예를 경험하였기에 문헌 고찰과 함께 보고하는 바이다.

참고문헌 (Reference)

1 "Sporadic fundic gland polyps" 158 : 1005-1010, 2001

2 "Positive predictive value of endoscopic features deemed typical of gastric fundic gland polyps" 36 : 399-402, 2003

3 "Incidence of fundic gland polyps in patients without familial adenomatous polyposis" 39 : 161-163, 1993

4 "Histologic classification of gastric polyps" 63 : 77-93, 1976

5 "High-grade dysplasia in sporadic fundic gland polyps" 15 : 1229-1233, 2003

6 "Glandular cysts of the gastric mucosa.Diagnosis and a pathogenetic hypothesis" 7 : 62-64, 1977

7 "Gastric polyps as precancerous lesions" 7 : 29-46, 1997

8 "Gastric polyps" 62 : 187-189, 1999

9 "Gastric lesions in familial adenomatosis coli:their incidence and histologic analysis" 9 : 269-283, 1978

10 "Gastric harmatomatous polyps in the absence of familial polyposis coli" 45 : 818-823, 1980

11 "Gastric glandular cysts-investigations into their genesis and relationship to colorectal epithelial tumors" 27 : 212-217, 1989

12 "Gastric fundic gland polyps" 114 : 422-423, 1998

13 "Gastric carcinoma and familial adenomatous polyposis(FAP)" 3 : 201-203, 1988

14 "Gastric adenocarcinoma associated with fundic gland polyps in a patient with attenuated familial adenomatous polyposis" 94 : 2275-2281, 1999

15 "Gastric adenocarcinoma and dysplasia in fundic gland polyps of a patient with attenuated adenomatous polyposis coli" 113 : 659-663, 1997

16 "Fundic gland polyps in familial adenomatous polyposis" 157 : 747-754, 2000

17 "Fundic gland polyps (Elster's cysts) of the gastric mucosa" 198 : 731-734, 2002

18 "Dysplastic changes in gastric fundic gland polyps of patients with familial adenomatous polyposis" 31 : 192-197, 1999

19 "Dysplasia and dysregulation of proliferation in foveolar and surface epithelia of fundic gland polyps from patients with familial adenomatous polyposis" 22 : 293-298, 1998

20 "Beta-catenin mutations in sporadic fundic gland polyps" 440 : 381-386, 2002