조기 난소 부전 = Premature Ovarian Failure

다국어 초록 (Multilingual Abstract)

Premature ovarian failure is defined as amenorrhea, hypergonadotropinemia, and estrogen deficiency in women under the age of 40 years, with a prevalence of 1%. In the majority of cases, the underlying cause is not identified. The known causes include genetic aberrations, autoimmune ovarian damage, iatrogenic following surgery, radiotherapy or chemotherapy for malignancies, and environmental factors (viral infections and toxins). The diagnosis is based on the finding of amenorrhea before age 40 years associated with FSH levels in the menopausal range. There is a particularly urgent need to determine the optimum therapeutic hormonal regimens in women with POF, both in terms of immediate symptom relief and for protection against the long-term sequelae of early menopause.