졸피뎀은 내성과 의존에서 안전한 약물인가? = The Tolerance and Dependence of Zolpidem, Not a ‘So Safe’ Drug?

다국어 초록 (Multilingual Abstract)

Zolpidem is a short-acting non-benzodiazepine hypnotics and has a short elimination half-life that was introduced in the 1980s. It has an favorable and safe profile compared to short-acting benzodiazepines (BZD), so it was expected that the disadvantages of BZD, such as sedation the next day and daytime sleepiness, as well as dependence and withdrawal symptoms, could be overcome. However, there is a growing body of case reports on zolpidem abuse and dependence, as well as withdrawal syndrome and epileptic seizures related to zolpidem discontinuation. Many subsequent studies have revealed that increasing concentrations of zolpidem result in loss of receptor selectivity, and binds to other subunits of the GABA-A receptor, similar to benzodiazepine. Nevertheless, zolpidem is one of the most commonly prescribed hypnotics in Korea, and related abuse and dependence cases are increasing. Thus, it is necessary to understand the developing mechanism of abuse and dependence related zolpidem, and be prepared with strategies to detoxify or intervene in any related condition.

목차 (Table of Contents)

• 서 론 졸피뎀의 약리학적 특징 GABA A 수용체와 의존 발생 GABA A 수용체와 내성의 발생 졸피뎀의 의존과 내성 발생 기전 졸피뎀 사용장애 환자의 분류 졸피뎀 금단증상의 해독 결 론