Streptozotocin에 의해 제1형 당뇨가 유발된 흰쥐 췌장 내분비선의 미세구조 변화

다국어 초록 (Multilingual Abstract)

The β-cells located in Langerhan's islet of pancreas produce insulin to regulate blood glucose
concentration. Streptozotocin (STZ) has been known to cause insulin dependent diabetes mellitus
(type I diabetes). The present study was carried to determine the morphological changes of
Langerhan's islet in pancreas by STZ. We conducted intraperitoneal injection of STZ (100 mg/kg)
for 3 days to rats. The results were as follows: The body weights of experimental group were not
increased. Blood glucose concentrations of experimental group were markedly increased compared
to control. Light microscopy (LM) revealed that Langerhan’s islets, or endocrine portions were
irregular in shape and decreased in size. On transmission electron microscopy (TEM), the β-cells
were fewer than control group. In addition, almost β-cells showed apoptotic features including
irregular nucleus, much heterochromatin and mitochondrial swelling or destruction. In the β-cell
cytoplasm, only a few insulin granules were observed. While pancreatic exocrine acinar cells and
the α-cell of Langerhan’s islet were not changed by STZ. The results suggest that STZ
treatment selectively causes the morphological and functional alterations of the β-cells in
Langerhan's islet of pancreas in rats.