뇌하수체선종의 경접형동 미세수술에 대한 임상적 분석 = Transsphenoidal Microsurgery of Pituitary Adenoma

다국어 초록 (Multilingual Abstract)

Anthor reviewed the 102 cases of pituitary adnomas treated via transsphenoidal adenomectomy from August 1977 to July 1987, at the Seoul National University Hospital.
The results obtained were as follows :
1) Male to female ratio of pituitary adenoma treated by TSA was 1 : 1.6.
2) Seventy-five cases(74％) of pituitary adenomas were functioning(endocrine-active)adenomas and twenty-seven cases(26％) were nonfunctioning cendocrine-inactive). Functioning adenomas were composed of prolactin-secreting adenoma(47％), GH-secreting adenoma(25％) and ACTH-secrting adenoma(6％).
3) According to radiologic classification, intrapituitary adenoma(Grade Ⅰ)was 4％, intrasellar adenoma(Grade Ⅱ)54％, diffuse adenoma(Grade Ⅲ)30％ & invasive adenoma(Grade Ⅳ)12％.
4) There was a significant relationship between prolactin value and size of prolactin-secreting adenoma, but no significant relationship was foung between h-GH value and size of GH-secreting adenoma.
5) In prolactin-secreting adenoma, microsurgical removal of the tumor follwed by bromocriptine administration was the most effective treatment modality.
6) In GH-secrting adenoma, decrease of fasting h-GH value was obtained more effectivly in cases who under went surgery plus radiation therapy than in cases with surgery alone.
7) In prolactin-secreting adenoma and GH-secreting adenoma, there was no relationship between degree of decrease in hormone values after TSA and size of the adenoma.
8) Improvement in visual acuity and visual field defect after TSA was obtained in 32％ of all pituitary adenomas. There was no operative mortality and complications after TSA were accompanied in 40％ of all cases, majority of which were a transient diabetes insipidus.